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Influence of Dose, Particle Size and Concentration on Dermal Penetration Efficacy of Curcumin
The influence of size, particle concentration and applied dose (finite vs. infinite dose) on the dermal penetration efficacy of curcumin was investigated in this study. For this, curcumin suspensions with different particle sizes (approx. 20 �m and approx. 250 nm) were produced in different conce...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Philipps-Universität Marburg
2023
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| Subjects: | |
| Online Access: | PDF Full Text |
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| Summary: | The influence of size, particle concentration and applied dose (finite vs. infinite dose)
on the dermal penetration efficacy of curcumin was investigated in this study. For this, curcumin
suspensions with different particle sizes (approx. 20 �m and approx. 250 nm) were produced in
different concentrations (0.625–5% (w/w)). The dermal penetration efficacy was determined semiquantitatively
on the ex vivo porcine ear model. The results demonstrated that the presence of
particles increases the dermal penetration efficacy of the active compounds being dissolved in the
water phase of the formulation. The reason for this is the formation of an aqueous meniscus that
develops between particles and skin due to the partial evaporation of water from the vehicle after
topical application. The aqueous meniscus contains dissolved active ingredients, and therefore
creates a small local spot with a locally high concentration gradient that leads to improved dermal
penetration. The increase in penetration efficacy depends on the number of particles in the vehicle, i.e.,
higher numbers of particles and longer contact times lead to higher penetration efficacy. Therefore,
nanocrystals with a high particle concentration were found to be the most suitable formulation
principle for efficient and deep dermal penetration of poorly water-soluble active ingredients. |
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| Item Description: | Gefördert durch den Open-Access-Publikationsfonds der UB Marburg. |
| DOI: | 10.3390/pharmaceutics15112645 |