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MAGED2 Depletion Promotes Stress-Induced Autophagy by Impairing the cAMP/PKA Pathway

Melanoma-associated antigen D2 (MAGED2) plays an essential role in activating the cAMP/PKA pathway under hypoxic conditions, which is crucial for stimulating renal salt reabsorption and thus explaining the transient variant of Bartter’s syndrome. The cAMP/PKA pathway is also known to regulate aut...

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Main Authors: Nasrah, Sadiq, Radi, Aline, Daberkow, Johanna K., Hummler, Helmut, Weber, Stefanie, Seaayfan, Elie, Kömhoff, Martin
Format: Article
Language:English
Published: Philipps-Universität Marburg 2023
Subjects:
hypoxia nephrogenesis
Bartter’s syndrome
cAMP
cellular stress
autophagy
MAGED2
G-alpha-S
Medizin
Medical sciences Medicine
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Call Number: urn:nbn:de:hebis:04-es2024-07596
Publication Date: 2024-01-22
Source: Erstveröffentlichung: Nasrah, S.; Radi, A.; Daberkow, J.K.; Hummler, H.; Weber, S.; Seaayfan, E.; Kömhoff, M. MAGED2 Depletion Promotes Stress-Induced Autophagy by Impairing the cAMP/PKA Pathway. Int. J. Mol. Sci. 2023, 24, 13433. https://doi.org/10.3390/ijms241713433
Downloads: 49 (2024)
License: https://creativecommons.org/licenses/by/4.0
Access URL: https://archiv.ub.uni-marburg.de/es/2024/0759
https://doi.org/10.3390/ijms241713433

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