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Changes in the degree of substitution of HES in vivo and their influence on methods for determining HES concentrations in plasma

The degree of substitution (DS) of HES describes the average proportion of substituted glucose molecules in a starch molecule. Although no quantitative studies of the in vivo behavior of the DS have been conducted so far, most pharmacokinetic studies to date have measured HES concentrations using th...

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Main Authors: Lukasewitz, Peter, Rischer, Philipp, Schedel, Nina, Stay, David, Wulf, Hinnerk, Stief, Thomas, Volberg, Christian
Format: Article
Language:English
Published: Philipps-Universität Marburg 2023
Subjects:
Glucose, Starches, Body weight, Enzyme, Blood plasma, Pharmacokinetics, Hydrolysis, Measurement
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Medical sciences Medicine
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Call Number: urn:nbn:de:hebis:04-es2024-07567
Publication Date: 2024-01-22
Source: Erstveröffentlichung: Lukasewitz P, Rischer P, Schedel N, Stay D, Wulf H, Stief T, et al. (2023) Changes in the degree of substitution of HES in vivo and their influence on methods for determining HES concentrations in plasma. PLoS ONE 18(8): e0290339. https://doi.org/10.1371/journal.pone.0290339
Downloads: 18 (2025), 109 (2024)
License: https://creativecommons.org/licenses/by/4.0
Access URL: https://archiv.ub.uni-marburg.de/es/2024/0756
https://doi.org/10.1371/journal.pone.0290339

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