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Association between Syncope and the 6-Month Incidence of Ischemic Stroke, Arrhythmia, Brain Tumor, Epilepsy, and Anxiety Disorder
Objectives: the aim of the present study is to investigate the associations between syncope and subsequent diagnoses of brain tumor, cardiac arrhythmia, stroke/transient ischemic attack (TIA), epilepsy, and anxiety disorder in a large outpatient population in Germany. Methods: This retrospective...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Philipps-Universität Marburg
2023
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| Subjects: | |
| Online Access: | PDF Full Text |
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| Summary: | Objectives: the aim of the present study is to investigate the associations between syncope
and subsequent diagnoses of brain tumor, cardiac arrhythmia, stroke/transient ischemic attack
(TIA), epilepsy, and anxiety disorder in a large outpatient population in Germany. Methods: This
retrospective cohort study uses data from the Disease Analyzer database (IQVIA). Adults who
received syncope diagnosis from one of 1284 general practices between January 2005 and December
2021 (index date) were included and matched (1:1) to individuals without syncope diagnosis using
a propensity score based on age, sex, the number of consultations during the follow-up period (up
to 6 months), and defined co-diagnoses documented within 12 months prior to and on the index
date. Finally, associations between syncope and subsequent outcome diagnoses were investigated
using multivariable logistic regression models. Results: Data related to 64,016 patients with and
64,016 patients without syncope (mean age 54.5 years, 56.5% female) were available. In total, 6.43%
of syncope patients and 2.14% of non-syncope patients were diagnosed with one of the five outcome
diagnoses within 6 months of the index date. There was a positive and significant association
between syncope and incidences of ischemic stroke/TIA (OR = 2.83, 95% CI = 2.41–3.32), arrhythmia
(OR = 3.81, 95% CI = 3.44–4.18), brain tumor (OR = 4.24, 95% CI = 2.50–7.19), epilepsy (OR = 5.52,
95% CI = 4.27–7.14), and anxiety disorder (OR = 1.99, 95% CI = 1.79–2.21). Conclusions: Syncope is
significantly associated with an increased risk of subsequent ischemic stroke/TIA, cardiac arrhythmia,
brain tumor, epilepsy, and anxiety disorder. Nevertheless, the cumulative incidences for all five
diagnoses are very low. |
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| Item Description: | Gefördert durch den Open-Access-Publikationsfonds der UB Marburg. |
| DOI: | 10.3390/healthcare11131913 |