Terahertz Spectroscopy for Non-Destructive Solid-State Investigation of Norfloxacin in Paper Tablets after Wet Granulation
(1) Background: Amorphous drug systems are an intensively studied approach to overcome the insufficient bioavailability of poorly soluble drugs. Here, paper tablets were studied, which were made from cellulose-based paper matrices loaded with norfloxacin. Moreover, wet granulation was introduced...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Philipps-Universität Marburg
2023
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| Subjects: | |
| Online Access: | PDF Full Text |
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| Summary: | (1) Background: Amorphous drug systems are an intensively studied approach to overcome
the insufficient bioavailability of poorly soluble drugs. Here, paper tablets were studied, which were
made from cellulose-based paper matrices loaded with norfloxacin. Moreover, wet granulation was
introduced as an additional processing step for improving the flowability of the solids, which is
necessary when considering production on an industrial scale. (2) Methods: The possible impact of
the wet granulation on the crystallinity of norfloxacin was studied by examining granulated and
non-granulated samples. Crystallinity investigations were performed using X-ray powder diffraction
(XRD) and terahertz time-domain spectroscopy (THz TDS). (3) Results: THz TDS allowed for a
more straightforward crystallinity assessment than XRD. Moreover, using THz TDS, it was possible
to detect minor changes in the crystallinity of the API after the granulation, whereas this was not
possible with the XRD analysis. (4) Conclusions: THz TDS results indicate a partial crystallization
of norfloxacin due to the wet granulation. Depending on the formulation, THz TDS can serve as a
beneficial and advantageous tool to determine the crystallinity of an API. |
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| Item Description: | Gefördert durch den Open-Access-Publikationsfonds der UB Marburg. |
| Physical Description: | 13 Pages |
| DOI: | 10.3390/pharmaceutics15071786 |