Complement Factor H-Related Proteins FHR1 and FHR5 Interact With Extracellular Matrix Ligands, Reduce Factor H Regulatory Activity and Enhance Complement Activation

Complement Factor H-Related Proteins FHR1 and FHR5 Interact With Extracellular Matrix Ligands, Reduce Factor H Regulatory Activity and Enhance Complement Activation

Components of the extracellular matrix (ECM), when exposed to body fluids may promote local complement activation and inflammation. Pathologic complement activation at the glomerular basement membrane and at the Bruch’s membrane is implicated in renal and eye diseases, respectively. Binding of solub...

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Main Authors: Papp, Alexandra, Papp, Krisztián, Uzonyi, Barbara, Cserhalmi, Marcell, Csincsi, Ádám I, Szábo, Zsóka, Bánlaki, Zsófia, Ermert, David, Prohászka, Zoltán, Erdei, Anna, Ferreira, Viviana P, Blom, Anna M, Józsi, Mihály
Contributor: Frontiers in Immunology (Issuing body)
Format: Article
Language:English
Published: Philipps-Universität Marburg 2022
Subjects:
immunology
Extracellular Matrix
Factor H
Medizin
Complement System
Medical sciences Medicine
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Call Number: urn:nbn:de:hebis:04-es2024-04055
Publication Date: 2024-01-16
Source: Erstveröffentlichung: Papp A, Papp K, Uzonyi B, Cserhalmi M, Csincsi A´ I, Szabo´ Z, Ba´ nlaki Z, Ermert D, Proha´ szka Z, Erdei A, Ferreira VP, Blom AM and Jo´ zsi M (2022) Complement Factor H-Related Proteins FHR1 and FHR5 Interact With Extracellular Matrix Ligands, Reduce Factor H Regulatory Activity and Enhance Complement Activation. Front. Immunol. 13:845953. https://doi.org/10.3389/fimmu.2022.845953
Downloads: 47 (2024)
License: https://creativecommons.org/licenses/by/4.0
Access URL: https://archiv.ub.uni-marburg.de/es/2024/0405
https://doi.org/10.3389/fimmu.2022.845953

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