Complement Factor H-Related Proteins FHR1 and FHR5 Interact With Extracellular Matrix Ligands, Reduce Factor H Regulatory Activity and Enhance Complement Activation

Components of the extracellular matrix (ECM), when exposed to body fluids may promote local complement activation and inflammation. Pathologic complement activation at the glomerular basement membrane and at the Bruch’s membrane is implicated in renal and eye diseases, respectively. Binding of solub...

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Main Authors: Papp, Alexandra, Papp, Krisztián, Uzonyi, Barbara, Cserhalmi, Marcell, Csincsi, Ádám I, Szábo, Zsóka, Bánlaki, Zsófia, Ermert, David, Prohászka, Zoltán, Erdei, Anna, Ferreira, Viviana P, Blom, Anna M, Józsi, Mihály
Contributor: Frontiers in Immunology (Issuing body)
Format: Article
Language:English
Published: Philipps-Universität Marburg 2022
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