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Getting cells into shape by calcium-dependent actin cross-linking proteins
The actin cytoskeleton represents a highly dynamic filament system providing cell structure and mechanical forces to drive a variety of cellular processes. The dynamics of the actin cytoskeleton are controlled by a number of conserved proteins that maintain the pool of actin monomers, promote act...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Philipps-Universität Marburg
2023
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| Subjects: | |
| Online Access: | PDF Full Text |
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| Summary: | The actin cytoskeleton represents a highly dynamic filament system providing cell
structure and mechanical forces to drive a variety of cellular processes. The
dynamics of the actin cytoskeleton are controlled by a number of conserved
proteins that maintain the pool of actin monomers, promote actin nucleation,
restrict the length of actin filaments and cross-link filaments into networks or
bundles. Previous work has been established that cytoplasmic calcium is an
important signal to rapidly relay information to the actin cytoskeleton, but the
underlying mechanisms remain poorly understood. Here, we summarize new
recent perspectives on how calcium fluxes are transduced to the actin
cytoskeleton in a physiological context. In this mini-review we will focus on
three calcium-binding EF-hand-containing actin cross-linking proteins, α-actinin,
plastin and EFHD2/Swiprosin-1, and how these conserved proteins affect the cell’s
actin reorganization in the context of cell migration and wound closure in
response to calcium. |
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| Item Description: | Gefördert durch den Open-Access-Publikationsfonds der UB Marburg. |
| DOI: | 10.3389/fcell.2023.1171930 |