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Effects of Monoamino-Oxidase-A (MAO-A) Inhibition on Skeletal Muscle Inflammation and Wasting through Pancreatic Ductal Adenocarcinoma in Triple Transgenic Mice

Cancer cachexia describes a syndrome of muscle wasting and lipolysis that is still largely untreatable and negatively impacts prognosis, mobility, and healthcare costs. Since upregulation of skeletal muscle monoamine-oxidase-A (MAO-A), a source of reactive oxygen species, may contribute to cachexia,...

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Main Authors: Schmich, Simon K. P., Keck, Jan, Bonaterra, Gabriel A., Bertoune, Mirjam, Adam, Anna, Wilhelm, Beate, Slater, Emily P., Schwarzbach, Hans, Fendrich, Volker, Kinscherf, Ralf, Hildebrandt, Wulf
Format: Article
Language:English
Published: Philipps-Universität Marburg 2023
Subjects:
harmine
skeletal muscle atrophy
cytokines
KPC model
E3-ligases
pancreatic cancer
Medizin
cachexia
Medical sciences Medicine
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Call Number: urn:nbn:de:hebis:04-es2024-02834
Publication Date: 2024-01-15
Source: Erstveröffentlichung: Schmich, S.K.P.; Keck, J.; Bonaterra, G.A.; Bertoune, M.; Adam, A.; Wilhelm, B.; Slater, E.P.; Schwarzbach, H.; Fendrich, V.; Kinscherf, R.; et al. Effects of Monoamino-Oxidase-A (MAO-A) Inhibition on Skeletal Muscle Inflammation and Wasting through Pancreatic Ductal Adenocarcinoma in Triple Transgenic Mice. Biomedicines 2023, 11, 912. https://doi.org/10.3390/biomedicines11030912
Downloads: 48 (2024)
License: https://creativecommons.org/licenses/by/4.0
Access URL: https://archiv.ub.uni-marburg.de/es/2024/0283
https://doi.org/10.3390/biomedicines11030912

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