IL18 Receptor Signaling Inhibits Intratumoral CD8+ T-Cell Migration in a Murine Pancreatic Cancer Model

In pancreatic ductal adenocarcinoma (PDAC), the infiltration of CD8+ cytotoxic T cells (CTLs) is an important factor in determining prognosis. The migration pattern and interaction behavior of intratumoral CTLs are pivotal to tumor rejection. NLRP3-dependent proinflammatory cytokines IL-1β and IL-18...

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Main Authors: Nasiri, Elena, Student, Malte, Roth, Katrin, Siti Utami, Nadya, Huber, Magdalena, Buchholz, Malte, Gress, Thomas M., Bauer, Christian
Format: Article
Language:English
Published: Philipps-Universität Marburg 2023
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Call Number: urn:nbn:de:hebis:04-es2024-02520
Publication Date: 2024-01-10
Source: Erstveröffentlichung: Nasiri, E.; Student, M.; Roth, K.; Siti Utami, N.; Huber, M.; Buchholz, M.; Gress, T.M.; Bauer, C. IL18 Receptor Signaling Inhibits Intratumoral CD8+ T-Cell Migration in a Murine Pancreatic Cancer Model. Cells 2023, 12, 456. https://doi.org/10.3390/cells12030456
Downloads: 33 (2024)
License: https://creativecommons.org/licenses/by/4.0
Access URL: https://archiv.ub.uni-marburg.de/es/2024/0252
https://doi.org/10.3390/cells12030456