TLR7 and IgM: Dangerous Partners in Autoimmunity

The B cell antigen receptor (BCR)-repertoire is capable of recognizing a nearly unlimited number of antigens. Inevitably, the random nature of antibody gene segment rearrangement, needed in order to provide mature B cells, will generate autoreactive specificities. Once tolerance mechanisms fail to b...

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Bibliographic Details

Main Authors:	Amendt, Timm, Yu, Philipp
Format:	Article
Language:	English
Published:	Philipps-Universität Marburg 2022
Subjects:	autoantibodies Medizin autoimmunity B cells TLR7 IgM Medical sciences Medicine
Online Access:	PDF Full Text
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