Development of Fluorescent AF64394 Analogues Enables Real-Time Binding Studies for the Orphan Class A GPCR GPR3

The orphan G protein-coupled receptor (oGPCR) GPR3 represents a potential drug target for the treatment of Alzheimer’s disease and metabolic disorders. However, the limited toolbox of pharmacological assays hampers the development of advanced ligands. Here, we developed a signaling pathway-independe...

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Bibliographic Details

Main Authors:	Merlin Bresinsky, Aida Shahraki, Peter Kolb, Steffen Pockes, Hannes Schihada
Contributor:	Journal of Medicinal Chemistry (Issuing body)
Format:	Article
Language:	English
Published:	Philipps-Universität Marburg 2023
Subjects:	Biolumineszenz-Resonanzenergietransfer, GPCR GPR3 Pharmakologie, Therapeutik orphan GPCR Fluoreszenzligand fluorescence ligand G-Protein gekoppelter Rezeptor G protein-coupled receptor (GPCR) BRET Pharmacology & therapeutics, prescription drugs
Online Access:	PDF Full Text
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