Development of Fluorescent AF64394 Analogues Enables Real-Time Binding Studies for the Orphan Class A GPCR GPR3

Development of Fluorescent AF64394 Analogues Enables Real-Time Binding Studies for the Orphan Class A GPCR GPR3

The orphan G protein-coupled receptor (oGPCR) GPR3 represents a potential drug target for the treatment of Alzheimer’s disease and metabolic disorders. However, the limited toolbox of pharmacological assays hampers the development of advanced ligands. Here, we developed a signaling pathway-independe...

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Main Authors: Merlin Bresinsky, Aida Shahraki, Peter Kolb, Steffen Pockes, Hannes Schihada
Contributor: Journal of Medicinal Chemistry (Issuing body)
Format: Article
Language:English
Published: Philipps-Universität Marburg 2023
Subjects:
Biolumineszenz-Resonanzenergietransfer,
GPCR
GPR3
Pharmakologie, Therapeutik
orphan GPCR
Fluoreszenzligand
fluorescence ligand
G-Protein gekoppelter Rezeptor
G protein-coupled receptor (GPCR)
BRET
Pharmacology & therapeutics, prescription drugs
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Call Number: urn:nbn:de:hebis:04-es2023-01646
Publication Date: 2023-11-13
Source: Erstveröffentlichung: Merlin Bresinsky, Aida Shahraki, Peter Kolb, Steffen Pockes, and Hannes Schihada Journal of Medicinal Chemistry 2023 66 (21), 15025-15041. https://doi.org/10.1021/acs.jmedchem.3c01707
Downloads: 31 (2024), 4 (2023)
License: https://creativecommons.org/licenses/by/4.0
Access URL: https://archiv.ub.uni-marburg.de/es/2023/0164
https://doi.org/10.1021/acs.jmedchem.3c01707

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