Partial p53 reactivation is sufficient to induce cancer regression

Impaired p53 function is one of the central molecular features of a tumor cell and even a partial reduction in p53 activity can increase the cancer risk in mice and men. From a therapeutic perspective it is noteworthy that tumor cells often become addicted to the absence of p53 providing a rationale...

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Main Authors: Klimovich, Boris, Meyer, Laura, Merle, Nastasja, Neumann, Michelle, König, Alexander M., Ananikidis, Nikolaos, Keber, Corinna U., Elmshäuser, Sabrina, Tomofeev, Oleg, Stiewe, Thorsten
Format: Article
Language:English
Published: Philipps-Universität Marburg 2022
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Call Number: urn:nbn:de:hebis:04-es2023-01215
Publication Date: 2023-09-04
Source: Erstveröffentlichung: Klimovich, B., Meyer, L., Merle, N. et al. Partial p53 reactivation is sufficient to induce cancer regression. J Exp Clin Cancer Res 41, 80 (2022). https://doi.org/10.1186/s13046-022-02269-6
Downloads: 32 (2024), 11 (2023)
License: https://creativecommons.org/licenses/by/4.0
Access URL: https://archiv.ub.uni-marburg.de/es/2023/0121
https://doi.org/10.1186/s13046-022-02269-6