Non-destructive crystallinity assessment of indomethacin in tablets made from smartFilms(R) using terahertz time-domain spectroscopy

We use terahertz (THz) time-domain spectroscopy (TDS) to assess the crystalline state of indomethacin (IM) when loaded in smartFilms®. We found that smartFilms favour the amorphous IM (A-IM) for low loading concentrations. For higher concentrations, IM recrystallizes in its α- crystalline form and t...

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Main Authors: Ornik, Jan, Heidrich, Lara, Schesny, Robert, Castro-Camus, Enrique, Keck, Cornelia M., Koch, Martin
Format: Article
Language:English
Published: Philipps-Universität Marburg 2022
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Call Number: urn:nbn:de:hebis:04-es2023-01181
Publication Date: 2023-09-04
Source: Erstveröffentlichung: Ornik, J., Heidrich, L., Schesny, R. et al. Non-destructive crystallinity assessment of indomethacin in tablets made from smartFilms(R) using terahertz time-domain spectroscopy. Sci Rep 12, 6099 (2022). https://doi.org/10.1038/s41598-022-10041-1
Downloads: 35 (2024), 38 (2023)
License: https://creativecommons.org/licenses/by-nc-sa/4.0
Access URL: https://archiv.ub.uni-marburg.de/es/2023/0118
https://doi.org/10.1038/s41598-022-10041-1