Enhanced firing of locus coeruleus neurons and SK channel dysfunction are conserved in distinct models of prodromal Parkinson’s disease

Parkinson’s disease (PD) is clinically defined by the presence of the cardinal motor symptoms, which are associated with a loss of dopaminergic nigrostriatal neurons in the substantia nigra pars compacta (SNpc). While SNpc neurons serve as the prototypical cell-type to study cellular vulnerability i...

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Main Authors: Matschke, Lina A., Komadowski, Marlene A., Stöhr, Annette, Lee, Bolam, Henrich, Martin T., Griesbach, Markus, Rinné, Susanne, Geibl, Fanni F., Chiu, Wei-Hua, Koprich, James B., Brotchie, Jonathan M., Kiper, Aytug K., Dolga, Amalia M., Oertel, Wolfgang H., Decher, Niels
Format: Article
Language:English
Published: Philipps-Universität Marburg 2022
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Call Number: urn:nbn:de:hebis:04-es2023-00846
Publication Date: 2023-07-13
Source: Erstveröffentlichung: Matschke, L.A., Komadowski, M.A., Stöhr, A. et al. Enhanced firing of locus coeruleus neurons and SK channel dysfunction are conserved in distinct models of prodromal Parkinson’s disease. Sci Rep 12, 3180 (2022). https://doi.org/10.1038/s41598-022-06832-1
Downloads: 27 (2024), 31 (2023)
License: https://creativecommons.org/licenses/by/4.0
Access URL: https://archiv.ub.uni-marburg.de/es/2023/0084
https://doi.org/10.1038/s41598-022-06832-1