MAGED2 Is Required under Hypoxia for cAMP Signaling by Inhibiting MDM2-Dependent Endocytosis of G-Alpha-S

MAGED2 Is Required under Hypoxia for cAMP Signaling by Inhibiting MDM2-Dependent Endocytosis of G-Alpha-S

Mutations in MAGED2 cause transient Bartter syndrome characterized by severe renal salt wasting in fetuses and infants, which leads to massive polyhydramnios causing preterm labor, extreme prematurity and perinatal death. Notably, this condition resolves spontaneously in parallel with developmental...

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Bibliographic Details
Main Authors: Seaayfan, Elie, Nasrah, Sadiq, Quell, Lea, Kleim, Maja, Weber, Stefanie, Meyer, Hemmo, Laghmani, Kamel, Kömhoff, Martin
Format: Article
Language:English
Published: Philipps-Universität Marburg 2022
Subjects:
Bartter
Medizin
hypoxia
MAGED2
MDM2
G-alpha-S
Medical sciences Medicine
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Call Number: urn:nbn:de:hebis:04-es2023-00501
Publication Date: 2023-05-16
Source: Erstveröffentlichung: Seaayfan, E.; Nasrah, S.; Quell, L.; Kleim, M.;Weber, S.; Meyer, H.; Laghmani, K.; Kömhoff, M. MAGED2 Is Required under Hypoxia for cAMP Signaling by Inhibiting MDM2-Dependent Endocytosis of G-Alpha-S. Cells 2022, 11, 2546. https://doi.org/10.3390/cells11162546
Downloads: 50 (2024), 63 (2023)
License: https://creativecommons.org/licenses/by/4.0
Access URL: https://archiv.ub.uni-marburg.de/es/2023/0050
https://doi.org/10.3390/cells11162546

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