MAGED2 Is Required under Hypoxia for cAMP Signaling by Inhibiting MDM2-Dependent Endocytosis of G-Alpha-S

Mutations in MAGED2 cause transient Bartter syndrome characterized by severe renal salt wasting in fetuses and infants, which leads to massive polyhydramnios causing preterm labor, extreme prematurity and perinatal death. Notably, this condition resolves spontaneously in parallel with developmental...

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Bibliographic Details

Main Authors:	Seaayfan, Elie, Nasrah, Sadiq, Quell, Lea, Kleim, Maja, Weber, Stefanie, Meyer, Hemmo, Laghmani, Kamel, Kömhoff, Martin
Format:	Article
Language:	English
Published:	Philipps-Universität Marburg 2022
Subjects:	Bartter Medizin hypoxia MAGED2 MDM2 G-alpha-S Medical sciences Medicine
Online Access:	PDF Full Text
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