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Sharing the wealth: The versatility of proteins targeted to peroxisomes and other organelles

Peroxisomes are eukaryotic organelles with critical functions in cellular energy and lipid metabolism. Depending on the organism, cell type, and developmental stage, they are involved in numerous other metabolic and regulatory pathways. Many peroxisomal functions require factors also relevant to oth...

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Bibliographic Details
Main Authors: Bittner, Elena, Stehlik, Thorsten, Freitag, Johannes
Format: Article
Language:English
Published: Philipps-Universität Marburg 2023
Subjects:
targeting signal
Endoplasmic reticulum
peroxisome
Mitochondria
dual targeting
Biowissenschaften, Biologie
Life sciences
Online Access:PDF Full Text
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Summary:Peroxisomes are eukaryotic organelles with critical functions in cellular energy and lipid metabolism. Depending on the organism, cell type, and developmental stage, they are involved in numerous other metabolic and regulatory pathways. Many peroxisomal functions require factors also relevant to other cellular compartments. Here, we review proteins shared by peroxisomes and at least one different site within the cell. We discuss the mechanisms to achieve dual targeting, their regulation, and functional consequences. Characterization of dual targeting is fundamental to understand how peroxisomes are integrated into the metabolic and regulatory circuits of eukaryotic cells.
Item Description:Gefördert durch den Open-Access-Publikationsfonds der UB Marburg.
Physical Description:17 Pages
DOI:10.3389/fcell.2022.934331

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