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Inflammation and Wasting of Skeletal Muscles in Kras-p53-Mutant Mice with Intraepithelial Neoplasia and Pancreatic Cancer — When Does Cachexia Start?

Skeletal muscle wasting critically impairs the survival and quality of life in patients with pancreatic ductal adenocarcinoma (PDAC). To identify the local factors initiating muscle wasting, we studied inflammation, fiber cross-sectional area (CSA), composition, amino acid metabolism and capillar...

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Main Authors: Hildebrand, Wulf, Keck, Jan, Schmich, Simon, Bonaterra, Gabriel A., Wilhelm, Beate, Schwarzbach, Hans, Eva, Anna, Bertoune, Mirjam, Slater, Emily P., Fendrich, Volker, Kinscherf, Ralf
Format: Article
Language:English
Published: Philipps-Universität Marburg 2023
Subjects:
cancer cachexia
weight loss
gastrointestinal cancer
cytokines
sarcopenia
Medizin
muscle atrophy
Medical sciences Medicine
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Call Number: urn:nbn:de:hebis:04-es2023-00196
Publication Date: 2023-03-06
Source: Erstveröffentlichung: Hildebrandt,W.; Keck, J.; Schmich, S.; Bonaterra, G.A.; Wilhelm, B.; Schwarzbach, H.; Eva, A.; Bertoune, M.; Slater, E.P.; Fendrich, V.; et al. Inflammation and Wasting of Skeletal Muscles in Kras-p53-Mutant Mice with Intraepithelial Neoplasia and Pancreatic Cancer—When Does Cachexia Start? Cells 2022, 11, 1607. https://doi.org/10.3390/cells11101607
Downloads: 6 (2025), 55 (2024), 38 (2023)
License: https://creativecommons.org/licenses/by/4.0
Access URL: https://archiv.ub.uni-marburg.de/es/2023/0019
https://doi.org/10.3390/cells11101607

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