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The Metalloprotease-Disintegrin ADAM8 Alters the Tumor Suppressor miR-181a-5p Expression Profile in Glioblastoma Thereby Contributing to Its Aggressiveness

Glioblastoma (GBM) as the most common and aggressive brain tumor is characterized by genetic heterogeneity, invasiveness, radio-/chemoresistance, and occurrence of GBM stem-like cells. The metalloprotease-disintegrin ADAM8 is highly expressed in GBM tumor and immune cells and correlates with poor...

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Main Authors: Schäfer, Agnes, Ever, Lara, Meier, Lara, Schlomann, Uwe, Bopp, Miriam H. A., Dreizner, Gian-Luca, Lassmann, Olivia, Ben Bacha, Aaron, Benescu, Andreea-Cristina, Pojskic, Mirza, Preußer, Christian, von Strandmann, Elke Pogge, Carl, Barbara, Nimsky, Christopher, Bartsch, Jörg W.
Format: Article
Language:English
Published: Philipps-Universität Marburg 2022
Subjects:
ADAM8, miR-181a-5p
miRNA
tumor microenvironment
MMP9
glioblastoma
Medizin
extracellular vesicles
MR spectroscopy
Medical sciences Medicine
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Call Number: urn:nbn:de:hebis:04-es2022-01606
Publication Date: 2022-11-22
Source: Erstveröffentlichung: Schäfer A, Evers L, Meier L, Schlomann U, Bopp MHA, Dreizner G-L, Lassmann O, Ben Bacha A, Benescu A-C, Pojskic M, Preußer C, von Strandmann EP, Carl B, Nimsky C and Bartsch JW (2022) The Metalloprotease- Disintegrin ADAM8 Alters the Tumor Suppressor miR-181a-5p Expression Profile in Glioblastoma Thereby Contributing to Its Aggressiveness. Front. Oncol. 12:826273. doi: https://doi.org/10.3389/fonc.2022.826273
Downloads: 89 (2024), 24 (2023), 4 (2022)
License: https://creativecommons.org/licenses/by/4.0
Access URL: https://archiv.ub.uni-marburg.de/es/2022/0160
https://doi.org/10.3389/fonc.2022.826273

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