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PEGylated Chitosan Nanoparticles Encapsulating Ascorbic Acid and Oxaliplatin Exhibit Dramatic Apoptotic Effects against Breast Cancer Cells

: This study aims to design a pH-responsive dual-loaded nanosystem based on PEGylated chitosan nanoparticles loaded with ascorbic acid (AA) and oxaliplatin (OX) for the effective treatment of breast cancer. In this regard, non-PEGylated and PEGylated chitosan nanoparticles (CS NPs) loaded with ei...

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Bibliographic Details
Main Authors: Fahmy, Sherif Ashraf, Ramzy, Asmaa, Mandour, Asmaa A., Nasr, Soad, Abdelnaser, Anwar, Bakowsky, Udo, Azzazy, Hassan Mohamed El-Said
Format: Article
Language:English
Published: Philipps-Universität Marburg 2022
Subjects:
breast cancer
PEG
ionic gelation method
oxaliplatin
Medizin
chitosan nanoparticles
ascorbic acid (vitamin C)
Medical sciences Medicine
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Call Number: urn:nbn:de:hebis:04-es2022-01523
Publication Date: 2022-09-01
Source: Erstveröffentlichung: Fahmy, S.A.; Ramzy, A.; Mandour, A.A.; Nasr, S.; Abdelnaser, A.; Bakowsky, U.; Azzazy, H.M.E.-S. PEGylated Chitosan Nanoparticles Encapsulating Ascorbic Acid and Oxaliplatin Exhibit Dramatic Apoptotic Effects against Breast Cancer Cells. Pharmaceutics 2022, 14, 407. https://doi.org/10.3390/pharmaceutics14020407
Downloads: 11 (2025), 75 (2024), 42 (2023), 9 (2022)
License: https://creativecommons.org/licenses/by/4.0
Access URL: https://archiv.ub.uni-marburg.de/es/2022/0152
https://doi.org/10.3390/pharmaceutics14020407

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