Showing 1 - 20 results of 66 for search 'Klebe, Gerhard (Prof.)', query time: 0.08s Refine Results
  1. 1
    Optimization of the Drug Design Process by Ligand Preorganization and Occupancy of Transient Binding Pockets Based on the Model Proteins Thrombin and Aldose Reductase
    by Sandner, Anna Sophie
    Published 2022
    Contributors: “...Klebe, Gerhard (Prof. Dr.)...”
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  2. 2
    Mutational Studies on 17β-HSD14, Serial Synchrotron X-ray Crystallography, Solubility Enhancement using Cyclodextrins and Fragment-Based Drug Discovery Multiple Blocks to Pave the Road of Drug Design
    by Badran, Mohammed
    Published 2021
    Contributors: “...Klebe, Gerhard (Prof. Dr.)...”
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  3. 3
    Neue Ansätze zur Entwicklung von Modulatoren der homodimeren tRNA-Guanin-Transglycosylase
    by Nguyen, Andreas
    Published 2020
    Contributors: “...Klebe, Gerhard (Prof. Dr.)...”
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  4. 4
    Fragment-basierte Leitstruktursuche am Beispiel der Proteinkinase A
    by Oebbeke, Matthias
    Published 2021
    Contributors: “...Klebe, Gerhard (Prof. Dr.)...”
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  5. 5
    From Serendipity to the Rational Design of Protein–Protein Interface Modulators Targeting a tRNA-Modifying Enzyme
    by Nguyen, Dzung
    Published 2020
    Contributors: “...Klebe, Gerhard (Prof. Dr.)...”
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  6. 6
    Thermodynamic, Kinetic and Crystallographic Investigations of Benzenesulfonamides as Ligands of Human Carbonic Anhydrase II
    by Glöckner, Steffen
    Published 2020
    Contributors: “...Klebe, Gerhard Prof. Dr....”
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  7. 7
    Do All Roads Really Lead to Rome? Learnings from Comparative Analysis using SPR, NMR, & X-Ray Crystallography to Optimize Fragment Screening in Drug Discovery.
    by Hassaan, Engi
    Published 2019
    Contributors: “...Klebe, Gerhard (Prof. Dr.)...”
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  8. 8
    Synthese von D-Phe/D-DiPhe-Pro-basierenden Liganden und deren biophysikalischen Charakterisierung zur Selektivitätsstudie von Thrombin und Trypsin sowie ein synthetischer Beitrag zur Darstellung von Inhibitoren der Aldose-Reduktase und Carboanhydrase II
    by Ngo, Trong Khang
    Published 2020
    Contributors: “...Klebe, Gerhard (Prof. Dr.)...”
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  9. 9
    Targeting Trypanosoma brucei FPPS by Fragment-based drug discovery
    by Münzker Lena
    Published 2019
    Contributors: “...Klebe, Gerhard (Prof. Dr.)...”
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  10. 10
    The Power of Fragments: FBLD approach to investigate protein structures
    by Magari, Francesca
    Published 2020
    Contributors: “...Klebe, Gerhard (Prof. Dr.)...”
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  11. 11
    Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery
    by Petrick, Joy Kristin
    Published 2019
    Contributors: “...Klebe, Gerhard (Prof. Dr.)...”
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  12. 12
    Identifizierung, Charakterisierung und Untersuchungen der Struktur-Wirkungs-Beziehung sowie des Mode of Action eines neuen antimikrobiellen Peptids aus Hirudo verbana
    by Müller, Daniela
    Published 2019
    Contributors: “...Klebe, Gerhard (Prof. Dr. rer. nat.)...”
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  13. 13
    Expanding the Toolbox for Computational Analysis in Rational Drug Discovery: Using Biomolecular Solvation to Predict Thermodynamic, Kinetic and Structural Properties of Protein-Ligand Complexes
    by Hüfner, Tobias
    Published 2019
    Contributors: “...Klebe, Gerhard (Prof. Dr.)...”
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  14. 14
    Inhibitor Synthesis and Biophysical Characterization of Protein–Ligand–Solvent Interactions An Analysis of the Thermodynamics and Kinetics of Ligand Binding to Thermolysin
    by Cramer, Jonathan
    Published 2017
    Contributors: “...Klebe, Gerhard (Prof. Dr.)...”
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  15. 15
    Characterisation and differentiation of kinase binding pockets in PKA and PIM1 by small molecule fragments using protein crystallography
    by Siefker, Christof
    Published 2018
    Contributors: “...Klebe, Gerhard (Prof. Dr.)...”
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  16. 16
    Structural Characterization of 17β-Hydroxysteroid Dehydrogenase Type 14 and Inhibitor Optimization Using Crystallography and Computational Techniques
    by Bertoletti, Nicole
    Published 2017
    Contributors: “...Klebe, Gerhard (Prof. Dr.)...”
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  17. 17
    Beyond Affinity: Drug-Kinase Interaction Put under the Microscope
    by Wienen-Schmidt, Barbara
    Published 2017
    Contributors: “...Klebe, Gerhard (Prof.)...”
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  18. 18
    Proteindynamik - Flexibilität in Zielproteinen des strukturbasierten Wirkstoffdesigns
    by Terwesten, Felix
    Published 2017
    Contributors: “...Klebe, Gerhard (Prof. Dr.)...”
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  19. 19
    Erkennen von Proteinoberflächen durch ungewöhnliche Substrat-analoge Inhibitoren am Beispiel der cAMP-abhängigen Proteinkinase A
    by Müller, Janis
    Published 2017
    Contributors: “...Klebe, Gerhard (Prof. Dr.)...”
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  20. 20
    Systematic Correlation of Structural, Thermodynamic and Residual Solvation Properties of Hydrophobic Substituents in Hydrophobic Pockets Using Thermolysin as a Case Study
    by Krimmer, Stefan Günter
    Published 2017
    Contributors: “...Klebe, Gerhard (Prof. Dr.)...”
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