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Titel:Influence of Dose, Particle Size and Concentration on Dermal Penetration Efficacy of Curcumin
Autor:Chaiprateep, Em-on
Weitere Verfasser:Wiemann, Sabrina; Eckert, Ralph W.; Raab, Christian; Sengupta, Soma; Keck, Cornelia M.
Veröffentlicht:2023
URI:https://archiv.ub.uni-marburg.de/es/2024/0799
DOI: https://doi.org/10.3390/pharmaceutics15112645
URN: urn:nbn:de:hebis:04-es2024-07991
DDC:570 Biowissenschaften, Biologie
Publikationsdatum:2024-01-24
Lizenz:https://creativecommons.org/licenses/by/4.0

Dokument

Schlagwörter:
aqueous meniscus, curcumin, nanocrystals, porcine skin, dermal penetration, ex-vivo model

Summary:
The influence of size, particle concentration and applied dose (finite vs. infinite dose) on the dermal penetration efficacy of curcumin was investigated in this study. For this, curcumin suspensions with different particle sizes (approx. 20 �m and approx. 250 nm) were produced in different concentrations (0.625–5% (w/w)). The dermal penetration efficacy was determined semiquantitatively on the ex vivo porcine ear model. The results demonstrated that the presence of particles increases the dermal penetration efficacy of the active compounds being dissolved in the water phase of the formulation. The reason for this is the formation of an aqueous meniscus that develops between particles and skin due to the partial evaporation of water from the vehicle after topical application. The aqueous meniscus contains dissolved active ingredients, and therefore creates a small local spot with a locally high concentration gradient that leads to improved dermal penetration. The increase in penetration efficacy depends on the number of particles in the vehicle, i.e., higher numbers of particles and longer contact times lead to higher penetration efficacy. Therefore, nanocrystals with a high particle concentration were found to be the most suitable formulation principle for efficient and deep dermal penetration of poorly water-soluble active ingredients.


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