Dokument
| Titel: | Association between stressful life events and grey matter volume in the medial prefrontal cortex: A 2-year longitudinal study |
| Autor: | Ringwald, Kai G. |
| Weitere Verfasser: | Pfarr, Julia-Katharina; Stein, Frederike; Brosch, Katharina; Meller, Tina; Thomas-Odenthal, Florian; Meinert, Susanne; Waltemate, Lena; Breuer, Fabian; Winter, Alexandra; Lemke, Hannah; Grotegerd, Dominik; Thiel, Katharina; Bauer, Jochen; Hahn, Tim; Jansen, Andreas; Dannlowski, Udo; Krug, Axel; Nenadic, Igor; Kircher, Tilo |
| Veröffentlicht: | 2022 |
| URI: | https://archiv.ub.uni-marburg.de/es/2024/0218 |
| DOI: | https://doi.org/10.1002/hbm.25869 |
| DDC: | 610 Medizin |
| Publikationsdatum: | 2024-01-09 |
| Lizenz: | https://creativecommons.org/licenses/by/4.0 |
| Schlagwörter: |
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| adverse childhood experiences, grey matter volume, stressful life events, magnetic resonance imaging, medialprefrontal cortex, voxel-based morphometry |
Summary:
Stressful life events (SLEs) in adulthood are a risk factor for various disorders such asdepression, cancer or infections. Part of this risk is mediated through pathways alter-ing brain physiology and structure. There is a lack of longitudinal studies examiningassociations between SLEs and brain structural changes. High-resolution structuralmagnetic resonance imaging data of 212 healthy subjects were acquired at baselineand after 2 years. Voxel-based morphometry was used to identify associationsbetween SLEs using the Life Events Questionnaire and grey matter volume (GMV)changes during the 2-year period in an ROI approach. Furthermore, we assessedadverse childhood experiences as a possible moderator of SLEs-GMV change associ-ations. SLEs were negatively associated with GMV changes in the left medial prefron-tal cortex. This association was stronger when subjects had experienced adversechildhood experiences. The medial prefrontal cortex has previously been associatedwith stress-related disorders. The present findings represent a potential neural basisof the diathesis-stress model of various disorders.
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