Publikationsserver der Universitätsbibliothek Marburg
Titel:Amygdala-Volumenveränderung bei Depression? Entwicklung und Anwendung eines Segmentierprotokolls für hochauflösende MRT
Autor:Wulff, Leonard
Weitere Beteiligte: Konrad, Carsten (Prof. Dr.)
Veröffentlicht:2018
URI:https://archiv.ub.uni-marburg.de/diss/z2018/0138
DOI: https://doi.org/10.17192/z2018.0138
URN: urn:nbn:de:hebis:04-z2018-01388
DDC:610 Medizin
Titel (trans.):Is there an amygdalar volume shift associated with MDD? Designing and applying a volumetric measurement protocol for high-definition MRI
Publikationsdatum:2018-02-08
Lizenz:https://rightsstatements.org/vocab/InC-NC/1.0/

Dokument

Schlagwörter:
Segmentierprotokoll, Amygdala, Depression, Kernspintomografie, MRT, MRI, Volumetrie, Morphometrie, Segmentation, Depression, Depression, Kernspintomografie, MDD, Amygdala, Morphometrie

Zusammenfassung:
Die unipolare Depression ist eine weltweit führende Ursache von Arbeitsunfähigkeit und Verlust an Lebensqualität. Es besteht daher ein großes Interesse an der Erforschung ihrer Pathogenese. In verschiedenen Hirnregionen wurden neuroanatomische Depressionsnetzwerke identifiziert in denen die Amygdala, ein Kerngebiet des limbischen Systems, einen der Knotenpunkte darstellt. Mittels morphometrischer Messungen im MRT wurden bei depressiven Menschen Volumenveränderungen der Amygdala festgestellt, bisherige Ergebnisse waren jedoch nicht einheitlich. Gründe für diese Divergenz sind möglicherweise nicht nur Unterschiede in den Segmentierprotokollen, sondern auch bisher unbekannte Einflussgrößen des Amygdalavolumens. Nach Evaluation bisheriger Segmentierprotokolle und ihrer neuroradiologischen Grenzlinien wurde in dieser Arbeit ein neues Protokoll zur Anwendung bei hoch auflösenden 3-Tesla-MR-Tomogrammen entwickelt. Durch die hohe Qualität der MRT und die im neuen Protokoll angewendete schrittweise Segmentierung aller drei Raumebenen konnte ein hoch reliables und valides Messinstrument des Amygdalavolumens entwickelt werden. Eine Anwendung dieses Protokolls auf MRT von depressiven Menschen und Gesunden zeigte eine signifikante bilaterale Volumenminderung der Amygdala bei Erkrankten. Es bestand ein Zusammenhang zwischen der Erkrankungsdauer und dem Ausmaß der Volumenminderung der rechten Amygdala. Die MRT-Morphometrie gibt methodenbedingt (Qualitätsverlust unter anderem durch Digitalisierung im MRT und durch Messungenauigkeit bei der Segmentierung) nur ein indirektes Abbild der tatsächlichen Neuroanatomie wieder. Trotz fehlender Genauigkeit absoluter Messungen ist es aber möglich, relative Zusammenhänge aufzuweisen. Durch eine zukünftige weitere Verbesserung der MR-Technik und für die Bildqualität optimierte Segmentierprotokolle wird die Messungenauigkeit sinken; die Verzerrung zwischen der Amygdala in vivo und ihrem segmentierten Abbild wird weiter minimiert werden. Perspektivisch ist eine Vereinheitlichung der Protokolle und Messinstrumente wünschenswert. So könnten die Ergebnisse verschiedener Studien miteinander verglichen und damit pathologische Muster leichter identifiziert werden.

Bibliographie / References

  1. Spampanato J, Polepalli J, Sah P (2010) Interneurons in the basolateral amygdala. Neuropharmacology doi:10.1016/j.neuropharm.2010.11.006
  2. Scherk H, Gruber O, Menzel P, Schneider-Axmann T, Kemmer C, Usher J, Reith W, Meyer J, Falkai P (2009) 5-HTTLPR genotype influences amygdala volume. Eur Arch Psychiatry Clin Neurosci 212-217: 259
  3. Weniger G, Lange C, Irle E (2006) Abnormal size of the amygdala predicts impaired emotional memory in major depressive disorder. J Affect Disord 94: 219-229
  4. Pruessner J C, Collins D L, Pruessner M, Evans A C (2001) Age and Gender Predict Volume Decline in the Anterior and Posterior Hippocampus in Early Adulthood. J Neurosci 21(1): 194-200
  5. Alzheimer's disease: an MRI analysis. Acta Neurol Scand 113: 40-45
  6. Fitzgerald FB, Laird AR, J Maller, Daskalakis ZJ (2008) A Meta-Analytic Study of Changes in Brain Activation in Depression. Biol Psychiatry 29: 708-714
  7. MacMaster FP, Mirza Y, Szeszko PR, Kmiecik LE, Easter PC, Taormina SP, Lynch M, Rose M, Moore GJ, Rosenberg DR (2008) Amygdala and Hippocampal Volumes in Familial Early Onset Major Depressive Disorder. Biol Psychiatry 63: 385-390
  8. Sheline YI, Gado MH, Price JL (1998) Amygdala core nuclei volumes are decreased in recurrent major depression. Neuroreport 9(9): 2023-2028
  9. Tamburo RJ, Siegle GJ, Stetten GD, Cois CA, Butters MA, F Reynolds C, Aizenstain HJ (2009) Amygdalae morphometry in late-life depression. Int J Geriatr Psychiatry 24: 837-846
  10. Altshuler LL, Bartzokis G, Grieder T, Curran J, Mintz J (1998) Amygdala enlargement in bipolar disorder and hippocampal reduction in schizophrenia: an MRI study demonstrating neuroanatomic specificity. Arch Gen Psychiatry 55: 663-664
  11. van Elst LT (2005) Amygdala morphometry in affective disorders (Letter to the editor). Am J Psychiatry 162(3): 629 XXII van Elst LT, Woermann FG, Lemieux L, Trimble MR (1999) Amygdala Enlargement in Dysthymia -A Volumetric Study of Patients with Temporal Lobe Epilepsy. Biol Psychiatry 46: 1614-1623
  12. Peluso MAM, Glahn DC, Matsuo K, Monkul ES, Najt P, Zamarripa F, Li J, Lancaster JL, Fox PT, Gao JH, Soares JC (2009) Amygdala hyperactivation in untreated depressed individuals. Psychiatry Res Neuroim 173: 158-161
  13. Amygdala Is Enlarged in Children But Not Adolescents with Autism: the Hippocampus Is Enlarged at All Ages. Neurobiol Dis 24(28): 6392-6401
  14. Szabo CA, Xiong J, Lancaster JL, Rainey L, Fox P (2001) Amygdalar and Hippocampal Volumetry in Control Participants: Differences Regarding Handedness. Am J Neuroradiol 22: 1342-1345
  15. Amygdala Volume Analysis in Female Twins with Major Depression. Biol Psychiatry 62(5): 415-422
  16. Savitz J, Nugent AC, Bogers W, Liu A, Sills R, Luckenbaugh DA, Bain EE, Price JL, Zarate C, Manji HK, Cannon DM, Marrett S, Charney DS, Drevets WC (2010) Amygdala volume in depressed patients with bipolar disorder assessed using high resolution 3T MRI: The impact of medication. Neuroimage 49: 2966-2976
  17. Hamilton JP, Siemer M, Gotlib IH (2008) Amygdala volume in major depressive disorder: a meta-analysis of magnetic resonance imaging studies. Mol Psychiatry 13: 993-1000
  18. van Eijndhoven P, van Wingen G, van Oijen K, Rijpkema M, Goraj B, Verkes RJ, Voshaar RO, Fernández G, Buitelaar J, Tendolkar I (2009) Amygdala Volume Marks the Acute State in the Early Course of Depression. Biol Psychiatry 65: 812-818
  19. Lorenzetti V, Allen NB, Whittle S, Yücel M (2010) Amygdala volumes in a sample of current depressed and remitted depressed patients and healthy controls. J Affect Disord 120: 112-119
  20. Hajek T, Kopecek M, Kozeny J, Gunde E, Alda M, Höschl, C (2009) Amygdala volumes in mood disorders -Meta-analysis of magnetic resonance volumetry studies. J Affect Disord 115: 395-410
  21. Lehéricy S, Baulac M, Chiras J, Piérot L, Martin N, Pillon B, Deweer B, B Dubois, Marsault C (1994) Amygdalohippocampal MR Volume Measurements in the Early Stages of Alzheimer Disease. Am J Neuroradiol 15: 929-937
  22. Caetano SC, Hatch JP, Brambilla P, Sassi RB, Nicoletti M, Mallinger AG, Frank E, Kupfer DJ, Keshavan MS, Soares JC (2004) Anatomical MRI study of hippocampus and amygdala in patients with current and remitted major depression. Psychiatry Res Neuroim 132: 141-147
  23. Watson C, Andermann F, Gloor P, Jones-Glotman M, Peters T, Avans A (1992) Anatomic basis of amygdaloid and hippocampal volume measurement by magnetic resonance imaging. Neurology 42: 1743-1750
  24. D. Drenckhahn (Hrsg.), Anatomie, Band 2 (16. Auflage Ausg.S. 515-517).
  25. Schläpfer T, Frick C (2007) Angst und Depression. 1. Auflage UNI-MED, Bremen Schumann CM, Hamstra J, Goodlin-Jones BL, Lotspeich LJ, Kwon H, Buonocore MH, Lammers CR, Reiss AL, Amaral DG (2004) The
  26. Campbell S, MacQueen G (2006) An update on regional brain volume differences associated with mood disorders. Curr Opin Psychiatry 19: 25- XII
  27. Mu Q, Xie J, Wen Z, Weng Y, Shuyun Z (1999) A Quantitative MR Study of the Hippocampal Formation, the Amygdala, and the Temporal Horn of the XIX Lateral Ventricle in Healthy Subjects 40 to 90 Years of Age. Am J Neuroradiol 20: 207-211
  28. Hariri AR, Drabant EM, Munoz KE, Kolachana BS, Mattay VS, Egan MF, Weinberger DR (2005) A susceptibility gene for affective disorders and the response of the human amygdala. Arch Gen Psychiat 62 (2): 146- 152
  29. Nieuwenhuys R, Vogel J, van Huiszen C (1991). Das Zentralnervensystem des Menschen (2. Auflage). (W. Lage, Übers.) Berlin, Heidelberg, Springer Verlag Pedraza O, Bowers D, Gilmore R (2004) Asymmetry of the hippocampus and amygdala in MRI volumetric measurements of normal adults. J Int Neuropsych Soc 10: 664-678
  30. Barta PE, Pearlson GD, Powers RE, Richards SS, Tune LE (1990) Auditory hallucinations and smaller superior temporal gyral volume in schizophrenia. Am J Psychiatry 147: 1457-1462
  31. Woods RP, Grafton ST, Watson JD, Sicotte NL, Maziotta JC (1998) Automated image registration: II. Intersubject validation of linear and nonlinear models. J Comput Assist Tomogr 22: 153-165
  32. von Gunten A, Fox NC, Cipolotti L, Ron MA (2000) A Volumetric Study of Hippocampus and Amygdala in Depressed Patients With Subjective Memory Problems. J Neuropsychiatry Clin Neurosci 12(4): 493-498
  33. XIV Good CD, Johnsrude IS, Ashburner J, Henson RNA, Friston KJ, Frackowiak RSJ (2001) A Voxel-Based Morphometric Study of Ageing in 465 Normal Adult Human Brains. Neuroimage 14: 21-36
  34. Bonelli RM, Kapfhammer HP, Pillay SS, Yurgelon-Todd DA (2006) Basal ganglia volumetric studies in affective disorder: what did we learn in the last 15 years? J Neural Transm 113: 255-268
  35. Koolschijn PCMP, van Haren NEM, Lensvelt-Mulders GJLM, Hulshoff Pol HE, Kahn RS (2009) Brain Volume Abnormalities in Major Depressive Disorder: A Meta-Analysis of Magnetic Resonance Imaging Studies. Hum Brain Mapp 30: 3719-3735
  36. Michaud CM, Murray CJL, Bloom BR (2001) Burden of disease -Implications for Future Research. JAMA 285: 535-539
  37. Bergouignan L, Chupin M, Czechowska Y, Kinkingnéhun S, Lemogne C, Le Bastard G, Lepage M, Garnero L, Colliot O, Fossati P (2009) Can voxel based morphometry, manual segmentation and automated segmentation equally detect hippocampal volume differences in acute depression? NeuroImage 45: 29-37
  38. Konarski JZ, McIntyre RS, Soczynska JK, Bottas A, Kennedy SH (2006) Clinical Translation of Neuroimaging Research in Mood Disorders. Psychiatry (Edgmont) 46-57
  39. Lazarus RS (1991) Cognition and Motivation in Emotion. Am Psychol 46: 352- XVII
  40. Howard MA, Cowell PE, Boucher J, Broks P, Mayes A, Farrant A, Roberts N (2000) Convergent neuroanatomical and behavioural evidence of an amygdala hypothesis of autism. Neuroreport 11 (13): 2931-2935
  41. Hwang JP, Lee TW, Tsai SJ, Chen TJ, Yang CH, Lirng JF, Tsai CF (2010) Cortical and Subcortical Abnormalities in Late-Onset Depression With History of Suicide Attempts Investigated With MRI and Voxel-Based Morphometry. J Geriatr Psychiatry 23(3): 171-184
  42. Amunts K, Kedo O, Kindler M, Pieperhoff P, Mohlberg H, Shah NJ, Habel U, Schneider F, Zilles K (2005) Cytoarchitectonic mapping of the human amygdala, hippocampal region and entorhinal cortex: intersubject variability and probability maps. Anat Embryol 210 343-352
  43. Burgmer M, Gaubitz M, Konrad C, Wrenger M, Hilgart S, Heuft G, Pfleiderer B (2009) Decreased Gray Matter Volumes in the Cingulo-Frontal Cortex and the Amygdala in Patients with Fibromyalgia. Psychosom Med 71: 566-573
  44. Holtzheimer PE, Mayberg HS (2010) Deep Brain Stimulation for Treatment- Resistant Depression. Am J Psychiatry 167(12): 1437-1444
  45. Krack P, Hariz MI, Baunez C, Guridi J, Obeso JA (2010) Deep Brain stimulation: from neurology to psychiatry? Trends Neurosci 33(10): 474- 484
  46. Konrad C, Ukas T, Nebel C, Arolt V, Toga AW, Narr KL (2009) Defining the human hippocampus in cerebral magnetic resonance images -An overview of current segmentation protocols. Neuroimage 47: 1185-1195
  47. Frodl TS, Koutsouleris N, Bottlender R, Born C, Jäger M, Scupin I, Reiser M, Möller HJ, Meisenzahl EM (2008b) Depression-Related Variation in Brain Morphology Over 3 Years -Effects of Stress? Arch Gen Psychiatry 65(10): 1156-1165
  48. Vollmert C, Tost H, Brassen S, Jatzko A, Braus DF (2004) Depression und moderne Bildgebung -Eine Übersicht des aktuellen Forschungsstandes zur Anwendung bildgebender Verfahren bei depressiven Störungen.
  49. Hilpert P (1928) Der Mandelkern des Menschen. J Psychol Neurol 36: 44-74
  50. Saß H, Wittchen H, Zaudig M (1996). Diagnostisches und Statistisches Manual Psychischer Störungen DSM-IV: übersetzt nach der vierten Auflage des Diagnostic and statistical manual of mental disorders der American Psychiatric Association. Göttingen, Bern, Toronto, Seattle, Hogrefe
  51. Marneros A (2009) Die Psychiatrie hat 200. Geburtstag. Ein Grund zum Feiern? Nervenarzt 80 (5): 598-604
  52. Bremner JD (1999) Does Stress Damage the Brain? Biol Psychiatry 45: 797- 805
  53. Frodl T, Jäger M, Smajstrlova I, Born C, Bottlender R, Palladino T, Reiser M, Möller HJ, Meisenzahl EM (2008a) Effect of hippocampal and amygdala volumes on clinical outcomes in major depression: a 3-year prospective magnetic resonance imaging study. J Psychiatry Neurosci 33(5): 423-430
  54. Rager G, Zenker W, Braak H, Braak E, Nitsch R, Asan E (2004). Endhirn - Paläokortex, subkortikale Kerne mit Basalganglien. In A. Benninghoff, &
  55. Wagner G, Koch K, Schachtzabel C, Reichenbach JR, Sauer H, Schlösser RGM (2008) Enhanced rostral anterior cingulate cortex activation during cognitive control is related to orbitofrontal volume reduction in unipolar depression. J Psychiatry Neurosc 33(3): 199-208
  56. Lange C, Irle E (2004) Enlarged amygdala volume and reduced hippocampal volume in young women with major depression. Psychol Med 34: 1059- 1064
  57. Frodl T, Meisenzahl E, Zetzsche T, Bottlender R, Born C, Groll C, Jäger M, Leinsinger G, Hahn K, Möller HJ (2002) Enlargement of the Amygdala in Patients with a First Episode of Major Depression. Biol Psychiatry 51: 708-714
  58. Niemann K, Hammers A, Coenen VA, Thron A, Klosterkötter J (2000) Evidence of a smaller left hippocampus and left temporal horn in both patients with first episode schizophrenia and normal control subjects. Psychiatry Res Neuroim 99: 93-110
  59. Gur RC, Erwin RJ, Gur RE, Zwil AS, Heimberg C, Kraemer HC (1992) Facial Emotion Discrimination: II. Behavioural Findings in Depression. Psychiat Res 42: 241-251
  60. Monkul ES, Hatch JP, Nicoletti MA, Spence S, Brambilla P, Lacerda ALT, Sassi RB, Mallinger AG, Keshavan MS, Soares JC (2007) Fronto-limbic brain structures in suicidal and non-suicidal female patients with major depressive disorder. Mol Psychiatry 12: 360-366
  61. Roth G, Dicke U (2006). Funktionelle Neuroanatomie des limbischen Systems. In H. Förstl, M. Hautzinger, G. Roth, Neurobiologie psychischer Störungen (1. Auflage Ausg.S. 3-74). Heidelberg, Springer
  62. Hamidi M, Drevets WC, Price JL (2004) Glial Reduction in Amygdala in Major Depressive Disorder Is Due to Oligodendrocytes. Biol Psychiatry 55: 563- 569
  63. Mak AKY, Wong MMC, Han S, Lee TMC (2009) Gray matter reduction associated with emotion regulation in female outpatients with major depressive disorder: A voxel-based morphometry study. Prog Neuropsychopharmacol 33: 1184-1190
  64. Keller J, Shen L, Gomez RG, Garrett A, Solvason HB, Reiss A, Schatzberg AF (2008) Hippocampal and Amygdalar Volumes in Psychotic and Nonpsychotic Unipolar Depression. Am J Psychiatry 165: 872-880
  65. Anstey KJ, Maller JJ, Meslin C, Christensen H, Jorm AF, Wen W, Sachdev P (2004) Hippocampal and amygdalar volumes in relation to handedness in adults aged 60-64. Neuroreport 15(18): 2825-2829
  66. Bremner JD, Narayan M, Anderson ER, Staib LH, Miller HL, Charney DS (2000) Hippocampal volume reduction in major depression. Am J Psychiatry 157(1): 115-117
  67. Bogerts B, Liebermann JA, Ashtari M, Bilder RM, Degreef G, Lerner G, Celeste J, Masiar S (1993) Hippocampus-amygdala volumes and psychopathology in chronic schizophrenia. Biol Psychiatry 33: 236-246
  68. Andrade C, Rao NS (2010) How antidepressant drugs act: A primer on neuroplasticity as the eventual mediator of antidepressant efficacy. Indian J Psychiatry 52(4): 378-386
  69. Adolphs R, Tranel D, Damasio H, Damasio H (1994) Impaired recognition of emotion in facial expressions following bilateral damage to the human amygdala. Nature 372: 669-672
  70. Achten E, Deblaere K, De Wagter C, Van Damme F, Boon P, De Reuck J, Kunnen M (1998) Intra-and interobserver variability of MRI-based volume measurements of the hippocampus and amygdala using the manual ray-tracing method. Neuroradiology 40: 558-566
  71. Kanner AM (2004) Is major depression a neurologic disorder with psychiatric symptoms? Epilepsy Behav 5: 636-644
  72. McDonald AJ (2003) Is There an Amygdala and How Far Does It Extend? Ann NY Acad Sci 985: 1-21
  73. Frodl T, Meisenzahl EM, Zetzsche T, Born C, Jäger M, Groll C, Bottlender R, Leinsinger G, Möller H J (2003) Larger Amygdala Volumes in First Depressive Episode as Compared to Recurrent Major Depression and Healthy Control Subjects. Biol Psychiatry 53: 338-344
  74. Baas D, Aleman A, Kahn RS (2004) Lateralization of amygdala activation: a systematic review of functional neuroimaging studies. Brain Res Rev 45: 96-103
  75. Johnson SA, Wang JF, Sun X, McEwen BS, Chattarji S, Young LT (2009) Lithium treatment prevents stress-induced dendritic remodeling in the rodent amygdala. Neuroscience 163: 34-39
  76. Campbell S, Marriot M, Nahmias C, MacQueen GM (2004) Lower Hippocampal Volume in Patients Suffering From Depression: A Meta-Analysis. Am J Psychiatry 161: 598-607
  77. Bowley MP, Drevets WC, Öngür D, Price JL (2002) Low Glial Numbers in the Amygdala in Major Depressive Disorder. Biol Psychiatry 52: 404-412
  78. David AS, Brierley B, Shaw P (2002) Measuring amygdala volume (Correspondence). Brit J Psychiat 181: 255-256
  79. Mori E, Yoneda Y, Yamashita H, Hirono N, Ikeda M, Yamadori A (1997) Medial temporal structures relate to memory impairment in Alzheimer's disease: an MRI volumetric study. J Neurol Neurosurg Psychiatry 63: 214-221
  80. Honeycutt NA, Smith PD, Aylward E, Li Q, Chan M, Barta PE, Pearlson GD (1998) Mesial temporal lobe measurements on magnetic resonance imaging scans. Psychiatry Res Neuroim 83: 85-94
  81. Evans DL, Charney DS (2003) Mood Disorders and Medical Illness: A Major Public Health Problem. Biol Psychiatry 21(1): 177-180
  82. Brambilla P, Harenski K, Nicoletti M, Sassi RB, Mallinger AG, Frank E, Kupfer DJ, Keshavan MS, Soares JC (2003) MRI investigation of temporal lobe structures in bipolar patients. J Psychiatry Res 37: 287-295
  83. Convit A, McHugh P, Wolf OT, de Leon MJ, Bobinski M, De Santi S, Roche A, Tsui W (1999) MRI volume of the amygdala: a reliable method allowing separation from the hippocampal formation. Psychiatry Res Neuroim 90: 113-123
  84. Cendes F, Andermann F, Gloor P, Evans A, Jones-Gotman M, Watson C, Melanson D, Olivier A, Peters T, Lopes-Cendes I, Leroux G (1993a) MRI volumetric measurements of amygdala and hippocampus in temporal lobe epilepsy. Neurology 43: 719-725
  85. Yoneda Y, Mori E, Yamashita H, Yamadori A (1994) MRI Volumetry of Medial Temporal Lobe Structures in Amnesia following Herpes Simplex Encephalitis. Eur Neurol 34: 243-252
  86. Tittgemeyer M, von Cramon DY (2004) MRT-basierte Morphometrie -Eine Bestandsaufnahme. Nervenarzt 75: 1172-1178
  87. Neuroanatomical and neuropsychological features of elderly euthymic depressed patients with early-and late-onset. J Neurol Sci 299: 19-23
  88. Reiss AL, Lee J, Freund L (1994) Neuroanatomy of fragile X syndrome: The temporal lobe. Neurology 44: 1317-1324
  89. Kalia M (2005) Neurobiological basis of depression: an update. Metabolism 54: 24-27
  90. Phillips ML, Drevets WC, Rauch SL, Lane R (2003) Neurobiology of Emotion Perception I: The Neural Basis of Normal Emotion Perception. Biol Psychiatry 54: 504-514
  91. Dannlowski U, Konrad C, Arolt V, Suslow T (2009) Neurogenetik emotionaler Prozesse -Neuroimaging-Befunde als Endophänotypen der Depression. Nervenarzt 81: 24-31
  92. Drevets WC (2000) Neuroimaging Studies of Mood Disorders. Biol Psychiatry 48: 813-829
  93. Goldstein JM, Seidman LJ, Horton NJ, Makris N, Kennedy DN, Caviness Jr. VS, Faraone SV, Tsuang MT (2001) Normal Sexual Dimorphism of the Adult Human Brain Assessed by In Vivo Magnetic Resonance Imaging. Cerebral Cortex 11: 490-497
  94. Smith RC, Calderon M, Ravichandran GK, Largen J, Vroulis G, Shvartsburd A, Gordon J, Schoolar JC (1984) Nuclear Magnetic Resonance in Schizophrenia: A Preliminary Study. Psychiatry Res 12: 137-147
  95. Hegerl U, Althaus D, Niklewski G, Schmidtke A (2003) Optimierte Versorgung depressiver Patienten und Suizidprävention. Dtsch Arztebl 100(42): A2732-A2737
  96. Szeszko PR, Robinson D, Alvir JMJ, Bilder RM, Lencz T, Ashtari M, Wu H, Bogerts B (1999) Orbital frontal and amygdala volume reductions in obsessive-compulsive disorder. Arch Gen Psychiatry 56: 913-919
  97. Drevets WC (2007) Orbitofrontal cortex function and structure in depression.
  98. Yoshikawa E, Matsuoka Y, Yamasue H, Inagaki M, Nakano T, Akechi T, Kobayakawa M, Fujimori M, Nakaya N, Akizuki N, Imoto S, Murakami K, Kasai K, Uchitomi Y (2006) Prefrontal Cortex and Amygdala Volume in First Minor or Major Depressive Episode After Cancer Diagnosis. Biol Psychiatry 59: 707-712
  99. Salvadore G, Nugent AC, Lemaitre H, Luckenbaugh DA, Tinsley R, Cannon DM, Neumeister A, Zarate CA, Drevets WC (2011) Prefrontal cortical abnormalities in currently depressed versus currently remitted patients with major depressive disorder. Neuroimage 54: 2643-2651
  100. Bonilha L, Kobayashi E, Cendes F, Li LM (2004) Protocol for Volumetric Segmentation of Medial Temporal Structures Using High-Resolution 3-D Magnetic Resonance Imaging. Hum Brain Mapp 22: 145-154
  101. Möller H, Laux G, Kapfhammer H (2003). Psychiatrie und Psychotherapie (2. Auflage). Berlin, Heidelberg, New York
  102. Coffey CE, Wilkinson WE, Weiner RD, Parashos IA, Djang WT, Webb MC, Figiel GS, Spritzer CE (1993) Quantitative Cerebral Anatomy in Depression. A Controlled Magnetic Resonance Imaging Study. Arch Gen Psychiatry 50: 7-16
  103. Mackay CE, Webb JA, Eldridge PR, Chadwick DW, Whitehouse GH, Roberts N (2000) Quantitative magnetic resonance imaging in consecutive patients evaluated for surgical treatment of temporal lobe epilepsy. Magn Reson Imaging 18: 1187-1199
  104. Mervaala E, Föhr J, Könönen M, Valkonen-Korhonen M, Vainio P, Partanen K, Partanen J, Tiihonen J, Viinamäki H, Karjalainen AK, Lehtonen J (2000) Quantitative MRI of the hippocampus and amygdala in severe depression. Psychol Med 30: 117-125
  105. Kronenberg G, van Elst LT, Regen F, Deuschle M, Heuser I, Colla M (2009) Reduced amygdala volume in newly admitted psychiatric in-patients with unipolar major depression. J Psychiatry Res 43: 1112-1117
  106. Kim MJ, Hamilton JP, Gotlib IH (2008) Reduced caudate gray matter volume in women with major depressive disorder. Psychiatry Res Neuroim 164: 114-122
  107. Tang Y, Wang F, Xie G, Liu J, Li L, Su L, Liu Y, Hu X, He Z, Blumenberg HP (2007) Reduced ventral anterior cingulate and amygdala volumes in medication-naïve females with major depressive disorder: A voxel-based morphometric magnetic resonance imaging study. Psychiatry Res Neuroim 156: 83-86
  108. van Tol MJ, van der Wee NJA, van den Heuvel OA, Nielen MMA, Demenescu LR, Aleman A, Renken R, van Buchem MA, Zitman FG, Veltman DJ (2010) Regional Brain Volume in Depression and Anxiety Disorders. Arch Gen Psychiatry 67: 1002-1011
  109. Grieve SM, Korgaonkar MS, Clark CR, Williams LM (2011) Regional heterogeneity in limbic maturational changes: Evidence from integrating cortical thickness, volumetric and diffusion tensor imaging measures. Neuroimage 55: 868-879
  110. Kates WR, Abrams MT, Kaufman WE, Breiter SN, Reiss AL (1997) Reliability and validity of MRI measurement of the amygdala and hippocampus in children with fragile X syndrome. Psychiatry Res Neuroim 75: 31-48
  111. Bartzokis G, Altshuler LL, Greiderab T, Curranc J, Keend B, Dixon WJ (1998) Reliability of medial temporal lobe volume measurements using reformatted three dimensional images. Psychiatry Res Neuroim 82(1): 11-24
  112. Morrison SE, Salzman CD (2010) Re-valuing the amygdala. Curr Opin Neurobiol 20: 221-230
  113. Hickie IB, Naismith SL, Ward PB, Scott EM, Mitchell PB, Schofield PR, Scimone A, Wilhelm K, Parker G (2007) Serotonin transporter gene status predicts XV caudate nucleus but not amygdala or hippocampal volumes in older persons with major depression. J Affect Disord 98: 137-142
  114. McIntyre RS, Soczynska JK, Konarski JZ, Woldeyohannes HO, Law CWY, Miranda A, Fulgosi D, Kennedy SH (2007) Should Depressive Syndromes Be Reclassified as "Metabolic Syndrome Type II"? Ann Clin Psychiatry 19(4): 257-264
  115. Pittenger C, Duman RS (2008) Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms. Neuropsychopharmacol 33: 88-109
  116. Lorenzetti V, Allen NB, Fornito A, Yücel M (2009) Structural brain abnormalities in major depressive disorder: A selective review of recent MRI studies. J Affect Disord 117: 1-17
  117. Killiany RJ, Moss MB, Albert MS, Sandor T, Tieman J, Jolesz F (1993) Temporal lobe regions on magnetic resonance imaging identify patients with early Alzheimer's disease. Arch Neurol 50: 949-954
  118. de Olmos JS, Heimer L (1999) The Concepts of the Ventral Striatopallidal System and Extended Amygdala. Ann N Y Acad Sci 877: 1-32
  119. WHO Department of Health Statistics and Informatics (2008). The global burden of disease: 2004 update, Abgerufen am 22. 05 2011 von WHO Health statistics and health information systems:
  120. Zald DH (2003) The human amygdala and the emotional evaluation of sensory stimuli. Brain Res Rev 41: 88-123
  121. Feinstein J, Adolphs R, Damasio A, Tranel D (2010) The Human Amygdala and the Induction and Experience of Fear. Curr Biol 21(1): 34-38
  122. Brierley B, Shaw P, David AS (2002) The human amygdala, a systematic review and meta-analysis of volumetric magnetic resonance imaging. Brain Res Rev 39: 84-105
  123. Duvernoy HM, Cattin F, Naidich T, Fatterpekar G, Raybaud C, Risold PY, Salvolini U, Scarabino T (2005) The Human Hippocampus -Functional Anatomy, Vascularization and Serial Sections with MRI. Berlin, Heidelberg, New York, Springer
  124. Duvernoy HM, Cattin F, Naidich T, Fatterpekar G, Raybaud C, Risold PY, Salvolini U, Scarabino T (2005) The Human Hippocampus -Functional Anatomy, Vascularization and Serial Sections with MRI. Berlin, Heidelberg, New York, Springer
  125. Bonilha L, Kobayashi E, Cendes F, Li LM (2005) The importance of accurate anatomic assessment for the volumetric analysis of the amygdala. Braz J Med Biol Res 38: 409-418
  126. Sergerie K, Chochol C, Armony JL (2008) The role of the amygdala in emotional processing: A quantitative meta-analysis of functional neuroimaging studies. Neurosci Biobehav Rev 32: 811-830 XXI
  127. Malykhin NV, Bouchard TP, Ogilvie CJ, Coupland NJ, Seres P, Camicioli R (2007) Three-dimensional volumetric analysis and reconstruction of amygdala and hippocampal head, body and tail. Psychiatry Res Neuroim 155: 155-165
  128. Bejjani BP, Damier P, Arnulf I, Thivard L, Bonnet AM, Dormont D, Cornu P, Pidoux B, Samson Y, Agid Y (1999) Transient Acute Depression Induced by High Frequency Deep Brain Stimulation. N Engl J Med 340: 1476- 1480
  129. den Heijer T, Vermeer SE, van Dijk EJ, Prins ND, Koudstaal PJ, Hofman A, Breteler MMB (2003) Type 2 diabetes and atrophy of medial temporal lobe structures on brain MRI. Diabetologia 46: 1604-1610
  130. Hastings RS, Parsey RV, Oquendo MA, Arango V, Mann JJ (2004) Volumetric Analysis of the Prefrontal Cortex, Amygdala, and Hippocampus in Major Depression. Neuropsychopharmacol 29: 952-959
  131. Xia J, Chen J, Zhou Y, Zhang J, Yang B, Xia L, Wang C (2004) Volumetric MRI Analysis of the Amygdala and Hippocampus in Subjects with Major De- pression. J Huazhong Univ Sci Technol Med Sci 24(5): 500-502
  132. Herrmann FR, Gold G, Canuto A (2010) Volumetric MRI changes, cognition and personality traits in old age depression. J Affect Disord 124: 275-282
  133. Bilir E, Craven W, Hugg J, Gilliam F, Martin R, Faught E, Kuzniecky R (1998) Volumetric MRI of the limbic system: anatomic determinants. Neuroradiology 40: 138-144
  134. Konarski JZ, McIntyre RS, Kennedy SH, Rafi-Tari S, Soczynska JK, Ketter TA (2008) Volumetric neuroimaging investigations in mood disorders: bipolar disorder versus major depressive disorder. Bipolar Disord 10: 1-37
  135. Brabec J, Rulseh A, Hoyt B, Vizek M, Horinek D, Hort J, Petrovicky P (2010) Volumetry of the human amygdala -An anatomical study. Psychiatry Res Neuroim 182: 67-72
  136. Swanson LW, Petrovich GD (1998) What is the amygdala? Trends Neurosci 21: 323-331
  137. Althaus D, Stefanek J, Hasford J, Hegerl U (2002) Wissensstand und Einstellungen der Allgemeinbevölkerung zu Symptomen, Ursachen und Behandlungsmöglichkeiten depressiver Erkrankungen. Nervenarzt 73: 659-664

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