Publikationsserver der Universitätsbibliothek Marburg

Titel:Contributions to the Asymmetric Synthesis of Octahedral Ruthenium(II) Complexes and to Bioactive Hexacoordinate Silicon Complexes
Autor:Fu, Chen
Weitere Beteiligte: Meggers, Eric (Prof. Dr.)
URN: urn:nbn:de:hebis:04-z2014-02431
DDC: Chemie
Titel(trans.):Beiträge zur asymmetrischen Synthese von Oktaedrische Ruthenium (II)-Komplexe und Bioactive sechsfach koordinierten Silicium-Komplexe


Ruthenium, Ruthenium, Silicon Complexes, asymmetrische Synthese, Asymmetric Synthesis, Silicium-Komplexe

This thesis mainly includes two parts: one is about the asymmetric synthesis of octahedral ruthenium complexes, and the other one is about the synthesis and investigation of the biological activities of octahedral silicon complexes. In the first part of this thesis, we started with a straightforward and economical method for the asymmetric synthesis of mononuclear ruthenium(II) complexes [Ru(pp)(pp’)(pp’’)](PF6)2 (pp = polypyridyl ligands) by using the readily available racemic starting material [Ru(pp)(pp’)Cl2] together with the natural amino acid L-proline. Next, we initially studied the asymmetric synthesis of dinuclear octahedral ruthenium(II) complexes, and synthesized an enantiomerically enriched dinuclear ruthenium complex for the first time. In the second part of this thesis, we developed the syntheses of hydrolytically stable octahedral silicon complexes, such as silicon arenediolate complexes, silicon arenediaminate complexes, enantiopure silicon BINOLate complexes, and silicon-ruthenium sandwich complexes. Furthermore, we investigated the biological activities of the octahedral silicon complexes and found that the silicon arenediolate complexes could be used as efficient DNA intercalators, while the bulky silicon-ruthenium sandwich complexes could detect mismatched DNA and serve as insertors.

Diese Doktorarbeit ist aus zwei Teilen zusammengesetzt. Bei dem ersten Teil handelt sich um die asymmetrische Synthese oktaedrischer Rutheniumkomplexe und in dem zweiten Teil wurden die Synthese sowie die biologische Aktivität oktaedrischer Siliciumkomplexe erforscht. Ausgehend von leicht herstellbarem racemischem Material [Ru(pp)(pp’)Cl2] (pp = Polypyridylliganden) wurden in dem ersten Teil dieser Arbeit die einkernigen Ruthenium(II)komplexe [Ru(pp)(pp’)(pp’’)](PF6)2 mit dem kommerziell verfügbarem Naturstoff L-Prolin bei einer einfachen und kostengünstigen asymmetrischen Synthese hergestell. Bei der ersten Untersuchung von doppelkernigen Ruthenium(II)komplexe wurde zum ersten Mal ein enantiomerenreiner doppelkerniger Ru-Komplex synthetisiert. In dem zweiten Teil dieser Arbeit wurden oktaedrische hydrolysestabile Siliciumkomplexe z.B. Siliciumkomplexe mit Arendiolat- und Arendiaminatliganden, enantiomerenreine Silicium-BINOLat-Komplexe und Silicium-Ruthenium-Sandwichkomplexe, erfolgreich synthetisiert. Weiterhin wurde die biologische Aktivität oktaedrischer Siliciumkomplexe erforscht. Dabei wurde herausgefunden, dass die Siliciumkomplexe mit Arendiolatliganden als effiziente DNA-Interkalatoren dienen konnten. Außerdem konnten Silicium-Ruthenium Sandwichkomplexe Basenfehlpaarungen in Duplex DNA stabilisieren.

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  46. Curriculum Vitae Name: Fu, Chen Gender: Male Date of the birth: 30. 05. 1985
  47. Email: ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ EDUCATION BACKGROUND 02. 2011~Present Ph.D. in Chemical Biology, Philipps-Universität Marburg Ph.D. thesis with Prof. Eric Meggers Research: Asymmetric synthesis of bioactive octahedral ruthenium complexes; Synthsis of octahedral silicon complexes as DNA binders and insertors.
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