Publikationsserver der Universitätsbibliothek Marburg
Titel:Neue Ansätze zur Entwicklung eines Ganzzellbiosensors
Autor:Vornholt, Wolfgang
Weitere Beteiligte: Keusgen, Michael (Prof. Dr.)
Veröffentlicht:2010
URI:https://archiv.ub.uni-marburg.de/diss/z2010/0458
DOI: https://doi.org/10.17192/z2010.0458
URN: urn:nbn:de:hebis:04-z2010-04586
DDC: Naturwissenschaften
Titel (trans.):New approaches for the development of a whole cell biosensor
Publikationsdatum:2010-07-08
Lizenz:https://rightsstatements.org/vocab/InC-NC/1.0/

Dokument

Schlagwörter:
Oberflächenplasmonresonanz, Lipopolysaccharid, Lipopolysaccharide, Lektine, Lectins

Zusammenfassung:
Unter Verwendung der Oberflächenplasmonresonanz (SPR) wurden unterschiedliche Modellapplikationen etabliert. Es wurden verschiedene Zuckeroberflächen erzeugt und durch ein Lektin-Screening charakterisiert. Das Bindungsverhalten derartiger Oberflächen wurde daraufhin an NCI-H125- sowie an Lewis Lung-Zellen untersucht. Im Hinblick auf eine Mistellektinbestimmung in Fertigarzneimitteln zur Krebstherapie wurde ein Mistellektin-Assay entwickelt. Die Detektion des rekombinanten Mistellektin I (MLI) erfolgte durch zwei unterschiedliche monoklonale Anti-MLI-Antikörper. Eine weitere Modellapplikation war die Visualisierung des nicht enzymatischen Schichtdickenabbaus des Polyethylencarbonats durch Superoxidradikalanionen unter Verwendung von murinen Makrophagen der Zelllinie J774A.1. Die Abbaugeschwindigkeit konnte mit den Triggerfaktoren Concanavalin A, LPS aus Escherichia coli und Salmonella typhimurium beeinflusst werden. Gram negative Bakterien als Trigger für Makrophagen wurden über ein Bakterienmembranmodell nachgeahmt. Hierfür wurden Liposomen mit Lipopolysaccharid aus Legionella pneumophila und Salmonella typhimurium funktionalisiert und mittels spezifischer Antikörper detektiert. Eine weitere Form des Triggerns der murinen Makrophagen der Zelllinie J774A.1 wurde mit LPS-gekoppelten Magnetic Beads auf der LAPS (lichtadressierbarer potentiometrischer Sensor) Messplattform umgesetzt. Unter Zuhilfenahme eines Permanentmagneten wurde ein Konzentrationsgradient in der Messlösung erzeugt. Die metabolische Aktivität der Makrophagen konnte so in Form der Änderung des pH-Wertes gezeigt werden.

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