Dokument
| Titel: | Cyfra 21-1 as a serum tumor marker for follow up of patients with laryngeal and hypopharyngeal squamous cell carcinoma |
| Autor: | Al-Shagahin, Hani |
| Weitere Beteiligte: | Werner, Jochen (Prof.) |
| Veröffentlicht: | 2009 |
| URI: | https://archiv.ub.uni-marburg.de/diss/z2009/0796 |
| URN: | urn:nbn:de:hebis:04-z2009-07963 |
| DOI: | https://doi.org/10.17192/z2009.0796 |
| DDC: | 610 Medizin |
| Titel (trans.): | Cyfra 21-1 als Serum Tumor Marker |
| Publikationsdatum: | 2010-01-26 |
| Lizenz: | https://rightsstatements.org/vocab/InC-NC/1.0/ |
| Schlagwörter: |
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| Markers, Tumor |
Summary:
AIM: To evaluate the importance and potential of Cyfra21-1 as a tumor marker (TM) for follow-up of patients with squamous cell carcinoma (SCC) in laryngeal and hypopharyngeal cancer. PATIENTS AND METHODS: Cyfra21-1 serum levels of 50 patients with laryngeal and hypopharyngeal SCC were evaluated by ECLIA assay. Statistical analysis was performed using Kruskal-Wallis and Jonckheere-Terpstra tests. RESULTS: There was no significant correlation between Cyfra21-1 levels at the time of initial diagnosis and the clinicopathological parameters. The clinical performance of Cyfra 21-1 as an individual tumor marker for follow-up of patients was good. This is shown by the area under the curve (0.873) of their receiver operating characteristic curves. The sensitivity and specificity of Cyfra 21-1 at a cut-off 3.3 ng/ml ere 61.1% and 96.9% respectively. CONCLUSION: Cyfra 21-1 is not suitable for early diagnosis of SCC of the larynx and hypopharynx. An abrupt increase of Cyfra 21-1 in serial measurements indicates impending disease progression in individual patients.
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