Titel: | Carbonyl Reductases and Pluripotent HydroxysteroidDehydrogenases of the Short-Chain Dehydrogenase/ReductaseSuperfamily:Structural Aspects of Oligomerization in 3alpha-HydroxysteroidDehydrogenase /Carbonyl Reductase from Comamonas testosteroni:New Approaches for efficient Protein Design |
Autor: | Hoffmann-Geim, Frank |
Weitere Beteiligte: | Buckel, Wolfgang (Prof. Dr.) |
Veröffentlicht: | 2009 |
URI: | https://archiv.ub.uni-marburg.de/diss/z2009/0563 |
DOI: | https://doi.org/10.17192/z2009.0563 |
URN: | urn:nbn:de:hebis:04-z2009-05639 |
ISBN: | 978-3-8366-3391-8 |
DDC: | Biowissenschaften, Biologie |
Titel (trans.): | Carbonylreduktasen und pluripotente Hydroxysteroid Dehydrogenasen der Short-Chain Dehydrogenase/ Reduktase Superfamilie: Strukturell Aspekte der Oligomerisierung in 3 alpha-Hydroxysteroid Dehydrogenase/ Carbonyl Reduktase aus Comamonas testosteroni- Neue Ansätze für effizientes Protein Design |
Publikationsdatum: | 2009-10-08 |
Lizenz: | https://rightsstatements.org/vocab/InC-NC/1.0/ |
Schlagwörter: |
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Simulation, Modellierung, Carbonyl-Reductase, Röntgenstruktur, Drug Design, Hydroxysteroid-Dehydrogenasen, SDR, SDR, Molekulardynamik, 3alpha HSD/CR, Molekulardynamik, Molecular dynamic, Hydroxysteroiddehydrogenase |
Summary:
Carbonyl reduction of aldehydes, ketones and quinones to their corresponding hydroxy de-rivatives plays an important role in the phase-I metabolism of many endogenous (biogenic aldehydes, steroids, prostaglandins, reactive lipid peroxidation products) and xenobiotic (pharmacologic drugs, carcinogens, toxicants) compounds. Carbonyl-reducing enzymes are grouped into two large protein superfamilies, the aldo-keto reductases (AKR) and the short-chain dehydrogenases/reductases (SDR). Whereas aldehyde reductase and aldose reductase are AKRs, several forms of carbonyl reductase belong to the SDRs. In addition, there exist a variety of pluripotent hydroxysteroid dehydrogenases (HSDs) of both superfamilies which specifically catalyze the oxidoreduction at different positions of the steroid nucleus, and which also catalyze rather non-specifically the reductive metabolism of a great number of non-steroidal carbonyl compounds. The present review summarizes recent findings on car-bonyl reductases and pluripotent HSDs of the SDR protein superfamily.
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