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Über die Hemmung des Flavivirins Makrocyclische Peptidderivate als Inhibitoren der NS2B-NS3-Protease des Zika-Virus und des West-Nil-Virus
Das Flavivirin oder die NS2B-NS3-Protease ist ein Enzym, das essentiell für die Vermehrung aller Flavivirus-Spezies ist. In dieser Arbeit wurden die Möglichkeiten zur Hemmung des Flavivirins des Zika-Virus (ZIKV) und des West-Nil-Virus (WNV) durch cyclische Peptidderivate untersucht. Dazu wurden übe...
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| Định dạng: | Dissertation |
| Ngôn ngữ: | Tiếng Đức |
| Được phát hành: |
Philipps-Universität Marburg
2022
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| Những chủ đề: | |
| Truy cập trực tuyến: | Bài toàn văn PDF |
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Flavivirin or the NS2B-NS3 protease is an enzyme essential for the propargation of all Flavivirus species. In this work, the possibilities of inhibiting the Flavivirin of the Zika virus (ZIKV) and the West Nile virus (WNV) with cyclic peptide-derivatives were investigated. For this purpose, more than 100 compounds were synthesised and characterised in enzyme kinetic assays, X-ray crystallography and cell culture experiments. The observed structure activtiy relationships may serve as new starting points of the development of antiviral drugs.