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Advanced preclinical CRISPR mouse models to explore context-dependent effects of TP53 mutations in cancer
The tumor suppressor p53 is the most frequently mutated protein in cancer patients and exhibits a unique mutational spectrum that is dominated by missense mutations. In contrast to the most prevalent hotspot mutations, 70% of all missense mutations are non-hotspot mutations with yet poorly character...
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| 主要作者: | |
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| 其他作者: | |
| 格式: | Dissertation |
| 語言: | 英语 |
| 出版: |
Philipps-Universität Marburg
2023
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| 主題: | |
| 在線閱讀: | PDF-Volltext |
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PDF-Volltext| 索引號: |
urn:nbn:de:hebis:04-z2023-01780 |
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| Publikationsdatum: |
2023-03-21 |
| Datum der Annahme: |
2023-02-07 |
| Downloads: |
114 (2024), 118 (2023) |
| Lizenz: |
https://creativecommons.org/licenses/by-nc-sa/4.0 |
| Zugangs-URL: |
https://archiv.ub.uni-marburg.de/diss/z2023/0178 https://doi.org/10.17192/z2023.0178 |