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Advanced preclinical CRISPR mouse models to explore context-dependent effects of TP53 mutations in cancer
The tumor suppressor p53 is the most frequently mutated protein in cancer patients and exhibits a unique mutational spectrum that is dominated by missense mutations. In contrast to the most prevalent hotspot mutations, 70% of all missense mutations are non-hotspot mutations with yet poorly character...
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| Формат: | Dissertation |
| Мова: | Англійська |
| Опубліковано: |
Philipps-Universität Marburg
2023
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| Онлайн доступ: | PDF-повний текст |
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