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Brain morphological and functional correlates of genetic, psychological, prenatal and prodromal risk for major mental disorders and their behavioural links
Cross-sectional mri-studies comparing psychiatric patients with healthy individuals have shown that patients show brain morphometric as well as functional changes. However, it is unclear whether these are pathological factors or whether these neurobiological changes are simply a risk factor for ment...
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| Format: | Doctoral Thesis |
| Language: | English |
| Published: |
Philipps-Universität Marburg
2022
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| Online Access: | PDF Full Text |
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| Summary: | Cross-sectional mri-studies comparing psychiatric patients with healthy individuals have shown that patients show brain morphometric as well as functional changes. However, it is unclear whether these are pathological factors or whether these neurobiological changes are simply a risk factor for mental disorders, a consequence of therapy, only occur in certain subgroups.
Therefore, the influence of a broad spectrum of different risk factors for mental disorders on brain morphometry as well as function was investigated in the present study: polygenic risk scores for psychiatric disorders, temporal perspective, shortened prenatal development as well as an extremely high risk for the development of psychosis. It can be shown that these risk factors significantly influence brain structural parameters as well as brain function. Some of these changes also correlated with behavioural changes such as poorer cognitive performance. These behavioural correlates could be valuable diagnostic or prognostic markers and could also be important research targets for the development of new therapeutic approaches. |
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| Physical Description: | 171 Pages |
| DOI: | 10.17192/z2022.0195 |