Optimization of the Drug Design Process by Ligand Preorganization and Occupancy of Transient Binding Pockets Based on the Model Proteins Thrombin and Aldose Reductase

Sandner, Anna Sophie

Optimization of the Drug Design Process by Ligand Preorganization and Occupancy of Transient Binding Pockets Based on the Model Proteins Thrombin and Aldose Reductase

The design and development of a drug is complex and usually extends over many years. Different approaches can facilitate lead optimization. This work focuses on specific aspects that could lead to advances in drug discovery. After an introduction to drug design and the two studied target proteins,...

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Номзүйн дэлгэрэнгүй
Үндсэн зохиолч:	Sandner, Anna Sophie
Бусад зохиолчид:	Klebe, Gerhard (Prof. Dr.) (Дипломын ажлын зөвлөх)
Формат:	Dissertation
Хэл сонгох:	англи
Хэвлэсэн:	Philipps-Universität Marburg 2022
Нөхцлүүд:	Präorganisation secondary homeostasis sekundäre Homöostase Blutgerinnung Trypsin trypsin preorganization Medizin Aldosereduktase ligand preorganization aldose reductase ALR-2 Ligandenpräorganisation blood coagulation Thrombin transiente Tasche transient binding pocke Medical sciences Medicine
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Optimization of the Drug Design Process by Ligand Preorganization and Occupancy of Transient Binding Pockets Based on the Model Proteins Thrombin and Aldose Reductase

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