Optimization of the Drug Design Process by Ligand Preorganization and Occupancy of Transient Binding Pockets Based on the Model Proteins Thrombin and Aldose Reductase

Optimization of the Drug Design Process by Ligand Preorganization and Occupancy of Transient Binding Pockets Based on the Model Proteins Thrombin and Aldose Reductase

The design and development of a drug is complex and usually extends over many years. Different approaches can facilitate lead optimization. This work focuses on specific aspects that could lead to advances in drug discovery. After an introduction to drug design and the two studied target proteins,...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Hoofdauteur: Sandner, Anna Sophie
Andere auteurs: Klebe, Gerhard (Prof. Dr.) (Thesis begeleider)
Formaat: Dissertation
Taal:Engels
Gepubliceerd in: Philipps-Universität Marburg 2022
Onderwerpen:
Präorganisation
secondary homeostasis
sekundäre Homöostase
Blutgerinnung
Trypsin
trypsin
preorganization
Medizin
Aldosereduktase
ligand preorganization
aldose reductase
ALR-2
Ligandenpräorganisation
blood coagulation
Thrombin
transiente Tasche
transient binding pocke
Medical sciences Medicine
Online toegang:PDF Full text
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!
No references were found for this record.

Gelijkaardige items