Optimization of the Drug Design Process by Ligand Preorganization and Occupancy of Transient Binding Pockets Based on the Model Proteins Thrombin and Aldose Reductase

Optimization of the Drug Design Process by Ligand Preorganization and Occupancy of Transient Binding Pockets Based on the Model Proteins Thrombin and Aldose Reductase

The design and development of a drug is complex and usually extends over many years. Different approaches can facilitate lead optimization. This work focuses on specific aspects that could lead to advances in drug discovery. After an introduction to drug design and the two studied target proteins,...

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Bibliographic Details
Main Author: Sandner, Anna Sophie
Contributors: Klebe, Gerhard (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2022
Subjects:
Präorganisation
secondary homeostasis
sekundäre Homöostase
Blutgerinnung
Trypsin
trypsin
preorganization
Medizin
Aldosereduktase
ligand preorganization
aldose reductase
ALR-2
Ligandenpräorganisation
blood coagulation
Thrombin
transiente Tasche
transient binding pocke
Medical sciences Medicine
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Call Number: urn:nbn:de:hebis:04-z2022-01182
Publication Date: 2022-05-25
Date of Acceptance: 2022-04-12
Downloads: 112 (2024), 132 (2023), 40 (2022)
License: https://creativecommons.org/licenses/by-nc-sa/4.0
Access URL: https://archiv.ub.uni-marburg.de/diss/z2022/0118
https://doi.org/10.17192/z2022.0118

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