Mutational Studies on 17β-HSD14, Serial Synchrotron X-ray Crystallography, Solubility Enhancement using Cyclodextrins and Fragment-Based Drug Discovery Multiple Blocks to Pave the Road of Drug Design

Mutational Studies on 17β-HSD14, Serial Synchrotron X-ray Crystallography, Solubility Enhancement using Cyclodextrins and Fragment-Based Drug Discovery Multiple Blocks to Pave the Road of Drug Design

The first topic of this thesis (Chapter 2) presents a mutational study performed on 17β-hydroxysteroid dehydrogenase type 14 (17β-HSD14) S205 variant. Five different mutations were done with respect to five amino acids which are believed to have an essential role in the enzyme activity and assembly....

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Bibliografski detalji
Glavni autor: Badran, Mohammed
Daljnji autori: Klebe, Gerhard (Prof. Dr.) (Savjetnik disertacije)
Format: Dissertation
Jezik:engleski
Izdano: Philipps-Universität Marburg 2021
Teme:
Biowissenschaften, Biologie
Inhibitoren im Komplex mit dem Protein Strukturbestimmung Kristallstrukturen 17b-HSD14 Fragment Screening crystallography, Inhibitor-Protein com
Life sciences
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Detalji primjeraka od
Signatura: urn:nbn:de:hebis:04-z2021-00954
Datum izdanja: 2021-12-02
Datum der Annahme: 2020-11-06
Downloads: 42 (2024), 129 (2023), 119 (2022), 12 (2021)
Lizenz: https://rightsstatements.org/vocab/InC-NC/1.0/
URL pristupa: https://archiv.ub.uni-marburg.de/diss/z2021/0095
https://doi.org/10.17192/z2021.0095

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