Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery

Petrick, Joy Kristin

Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery

Trypanosoma cruzi (T. cruzi) is the causative agent of Chagas disease (CD), which mostly affects underprivileged populations in South and Central America. The current standard of care for this disease are the two empirically discovered drugs benznidazole and nifurtimox. They show low efficacy, diffi...

Descrición completa

Gardado en:

Detalles Bibliográficos
Autor Principal:	Petrick, Joy Kristin
Outros autores:	Klebe, Gerhard (Prof. Dr.) (BetreuerIn (Doktorarbeit))
Formato:	Dissertation
Idioma:	inglés
Publicado:	Philipps-Universität Marburg 2019
Schlagworte:	Pharmakologie, Therapeutik mevalonate farnesyl pyrophosphate kissing bug Isoprenoid FPPS Fragment-basierte Wirkstoffforschung FDPS Chagas disease Chagas fragment based drug discovery Protein-Kristallograph protein cry isoprenoid Vernachlässigte Krankheit Farnesylpyroposphate-Synthase neglected disease Pharmacology & therapeutics, prescription drugs
Acceso en liña:	Texto completo PDF
Tags:	Engadir etiqueta Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Sexa o primeiro en deixar un comentario!

Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery

Títulos similares