Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery

Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery

Trypanosoma cruzi (T. cruzi) is the causative agent of Chagas disease (CD), which mostly affects underprivileged populations in South and Central America. The current standard of care for this disease are the two empirically discovered drugs benznidazole and nifurtimox. They show low efficacy, diffi...

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Bibliographic Details
Main Author: Petrick, Joy Kristin
Contributors: Klebe, Gerhard (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2019
Subjects:
Pharmakologie, Therapeutik
mevalonate
farnesyl pyrophosphate
kissing bug
Isoprenoid
FPPS
Fragment-basierte Wirkstoffforschung
FDPS
Chagas disease
Chagas
fragment based drug discovery
Protein-Kristallograph
protein cry
isoprenoid
Vernachlässigte Krankheit
Farnesylpyroposphate-Synthase
neglected disease
Pharmacology & therapeutics, prescription drugs
Online Access:PDF Full Text
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