Selective cellular vulnerability and pathology progression patterns in two mouse models of Parkinson’s disease

Selective cellular vulnerability and pathology progression patterns in two mouse models of Parkinson’s disease

Parkinson's disease is a highly debilitating disorder classically characterized by the degeneration of dopaminergic midbrain neurons of the substantia nigra. The resulting nigrostriatal dopamine deficiency is thought to be responsible for the onset of the cardinal Parkinson's motor symptom...

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Bibliographic Details
Main Author: Geibl, Fanni Fruzsina
Contributors: Oertel, Wolfgang H. (Prof. Dr. med. Dr. h.c.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2019
Subjects:
adeno-associated viral vectors
alpha-Synuclein
Parkinson's disease
Medizin
Parkinson-Krankheit
alpha-synuclein
selektive Vulnerabilit
Locus coeruleus
selective vulnerab
Pedunculopontiner Kern
pedunculopontine nucleus
adeno-assoziierte Viren
preformed fibrils
präformierte Fibrillen
Medical sciences Medicine
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Call Number: urn:nbn:de:hebis:04-z2019-04237
Publication Date: 2020-05-25
Date of Acceptance: 2019-10-09
Downloads: 29 (2024), 68 (2023), 74 (2022), 45 (2021), 22 (2020)
License: https://creativecommons.org/licenses/by-nc-nd/4.0/
Access URL: https://archiv.ub.uni-marburg.de/diss/z2019/0423
https://doi.org/10.17192/z2019.0423

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