Characterisation and differentiation of kinase binding pockets in PKA and PIM1 by small molecule fragments using protein crystallography

Siefker, Christof

Characterisation and differentiation of kinase binding pockets in PKA and PIM1 by small molecule fragments using protein crystallography

The primary aim of this thesis was the crystallographic analysis of PKA and Pim1 crystals in complex with small fragment-like molecules to identify potential fragment binders in the protein kinase binding pockets. In the first subproject of this thesis, the similarities and differences between both...

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書誌詳細
第一著者:	Siefker, Christof
その他の著者:	Klebe, Gerhard (Prof. Dr.) (論文の指導者)
フォーマット:	Dissertation
言語:	英語
出版事項:	Philipps-Universität Marburg 2018
主題:	protein crystallography Proteinkristallographie fragments Fragmente Wirkstoffdesign PKA Pim1 Protein kinase Proteinkinasen drug design Pharmakologie, Therapeutik Pharmacology & therapeutics, prescription drugs
オンライン･アクセス:	PDFフルテキスト
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Characterisation and differentiation of kinase binding pockets in PKA and PIM1 by small molecule fragments using protein crystallography

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