Characterisation and differentiation of kinase binding pockets in PKA and PIM1 by small molecule fragments using protein crystallography

Characterisation and differentiation of kinase binding pockets in PKA and PIM1 by small molecule fragments using protein crystallography

The primary aim of this thesis was the crystallographic analysis of PKA and Pim1 crystals in complex with small fragment-like molecules to identify potential fragment binders in the protein kinase binding pockets. In the first subproject of this thesis, the similarities and differences between both...

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Bibliographic Details
Main Author: Siefker, Christof
Contributors: Klebe, Gerhard (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2018
Subjects:
protein crystallography
Proteinkristallographie
fragments
Fragmente
Wirkstoffdesign
PKA
Pim1
Protein kinase
Proteinkinasen
drug design
Pharmakologie, Therapeutik
Pharmacology & therapeutics, prescription drugs
Online Access:PDF Full Text
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