Characterisation and differentiation of kinase binding pockets in PKA and PIM1 by small molecule fragments using protein crystallography

Siefker, Christof

Characterisation and differentiation of kinase binding pockets in PKA and PIM1 by small molecule fragments using protein crystallography

The primary aim of this thesis was the crystallographic analysis of PKA and Pim1 crystals in complex with small fragment-like molecules to identify potential fragment binders in the protein kinase binding pockets. In the first subproject of this thesis, the similarities and differences between both...

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Bibliographische Detailangaben
1. Verfasser:	Siefker, Christof
Beteiligte:	Klebe, Gerhard (Prof. Dr.) (BetreuerIn (Doktorarbeit))
Format:	Dissertation
Sprache:	Englisch
Veröffentlicht:	Philipps-Universität Marburg 2018
Schlagworte:	protein crystallography Proteinkristallographie fragments Fragmente Wirkstoffdesign PKA Pim1 Protein kinase Proteinkinasen drug design Pharmakologie, Therapeutik Pharmacology & therapeutics, prescription drugs
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Characterisation and differentiation of kinase binding pockets in PKA and PIM1 by small molecule fragments using protein crystallography

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