Influence of the in vivo half-antibody exchange on the therapeutic efficacy of an IgG4 antibody-drug conjugate

Influence of the in vivo half-antibody exchange on the therapeutic efficacy of an IgG4 antibody-drug conjugate

A high number of therapeutic antibodies and their derivates e.g. antibody-drug conjugates (ADC) are under preclinical or clinical evaluation for the treatment of cancer. Most of those ADCs are based on the IgG1 or IgG4 subtype, depending on whether additional effector functions are desired or not. I...

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Detaylı Bibliyografya
Yazar: Herbener, Peter
Diğer Yazarlar: Maier, Uwe G. (Prof. Dr.) (Tez danışmanı)
Materyal Türü: Dissertation
Dil:İngilizce
Baskı/Yayın Bilgisi: Philipps-Universität Marburg 2018
Konular:
Biowissenschaften, Biologie
antibody
BT062
bispezifische Antikörper
Immunglobulin G
bispecific antibody
cytotoxicity
Antikörper
internalization
half-antibody
multip
IgG4
cancer
Internalisi
Indatuximab ravtansine
antibody-drug conjugate
Antikörper-Wirkstoff-Konjugat
ADC
immunoglobulin
Halbantikörper
Life sciences
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