Structural Characterization of 17β-Hydroxysteroid Dehydrogenase Type 14 and Inhibitor Optimization Using Crystallography and Computational Techniques

Bertoletti, Nicole

Structural Characterization of 17β-Hydroxysteroid Dehydrogenase Type 14 and Inhibitor Optimization Using Crystallography and Computational Techniques

17β-Hydroxysteroid dehydrogenase type 14 (17β-HSD14) is the latest identified subtype of 17β HSDs. In vivo this enzyme oxidizes the hydroxyl group at position 17 of estradiol (E2) and 5 androstenediol (5-diol) in the presence of NAD+ as cofactor. Two isoforms of this cytosolic protein exist that dif...

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Bibliografiska uppgifter
Huvudupphovsman:	Bertoletti, Nicole
Övriga upphovsmän:	Klebe, Gerhard (Prof. Dr.) (BetreuerIn (Doktorarbeit))
Materialtyp:	Dissertation
Språk:	engelska
Publicerad:	Philipps-Universität Marburg 2017
Ämnen:	17b-HSD14 Kristallstrukturen crystallography, Fragment Screening Drug design Biowissenschaften, Biologie Strukturbestimmung Inhibitor-Protein complex Inhibitoren im Komplex mit dem Protein Life sciences
Länkar:	PDF-fulltext
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Structural Characterization of 17β-Hydroxysteroid Dehydrogenase Type 14 and Inhibitor Optimization Using Crystallography and Computational Techniques

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