Structural Characterization of 17β-Hydroxysteroid Dehydrogenase Type 14 and Inhibitor Optimization Using Crystallography and Computational Techniques

17β-Hydroxysteroid dehydrogenase type 14 (17β-HSD14) is the latest identified subtype of 17β HSDs. In vivo this enzyme oxidizes the hydroxyl group at position 17 of estradiol (E2) and 5 androstenediol (5-diol) in the presence of NAD+ as cofactor. Two isoforms of this cytosolic protein exist that dif...

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Hoofdauteur: Bertoletti, Nicole
Andere auteurs: Klebe, Gerhard (Prof. Dr.) (Thesis begeleider)
Formaat: Dissertation
Taal:Engels
Gepubliceerd in: Philipps-Universität Marburg 2017
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Plaatsingsnummer: urn:nbn:de:hebis:04-z2017-06718
Publicatiedatum: 2018-05-07
Datum der Annahme: 2017-10-04
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URL naar item: https://archiv.ub.uni-marburg.de/diss/z2017/0671
https://doi.org/10.17192/z2017.0671