Structural Characterization of 17β-Hydroxysteroid Dehydrogenase Type 14 and Inhibitor Optimization Using Crystallography and Computational Techniques
17β-Hydroxysteroid dehydrogenase type 14 (17β-HSD14) is the latest identified subtype of 17β HSDs. In vivo this enzyme oxidizes the hydroxyl group at position 17 of estradiol (E2) and 5 androstenediol (5-diol) in the presence of NAD+ as cofactor. Two isoforms of this cytosolic protein exist that dif...
Sábháilte in:
Príomhchruthaitheoir: | |
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Rannpháirtithe: | |
Formáid: | Dissertation |
Teanga: | Béarla |
Foilsithe / Cruthaithe: |
Philipps-Universität Marburg
2017
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Ábhair: | |
Rochtain ar líne: | An téacs iomlán mar PDF |
Clibeanna: |
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Ar líne
An téacs iomlán mar PDFGairmuimhir: |
urn:nbn:de:hebis:04-z2017-06718 |
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Dáta a fhoilsithe: |
2018-05-07 |
Datum der Annahme: |
2017-10-04 |
Downloads: |
47 (2024), 121 (2023), 122 (2022), 158 (2021), 174 (2020), 94 (2019), 4 (2018) |
Lizenz: |
https://rightsstatements.org/vocab/InC-NC/1.0/ |
URL Rochtana: |
https://archiv.ub.uni-marburg.de/diss/z2017/0671 https://doi.org/10.17192/z2017.0671 |