The species-specific effects of guinea pig adaptive mutations in Marburg virus VP40 and L on the protein’s functions and viral fitness

The species-specific effects of guinea pig adaptive mutations in Marburg virus VP40 and L on the protein’s functions and viral fitness

Marburg virus (MARV) is a highly pathogenic virus that causes severe, often lethal diseases specifically in humans and non-human primates. In rodents MARV is non-pathogenic. However, sequential passaging of MARV in rodents results in selection of a rodent-lethal virus. Lofts et al. established a gui...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awdur: Köhler, Alexander
Awduron Eraill: Becker, Stephan (Prof. Dr.) (Cynghorydd traethodau ymchwil)
Fformat: Dissertation
Iaith:Saesneg
Cyhoeddwyd: Philipps-Universität Marburg 2017
Pynciau:
Virologie
Virale Fitness
Biowissenschaften, Biologie
Medizin
VP40
L
Marburg Virus
Adaption
virale Polymerase
Matrix Protein
Life sciences
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Manylion daliadau o
Rhif Galw: urn:nbn:de:hebis:04-z2017-03377
Dyddiad Cyhoeddi: 2017-06-12
Datum der Annahme: 2017-05-10
Downloads: 41 (2024), 106 (2023), 97 (2022), 109 (2021), 122 (2020), 112 (2019), 40 (2018)
Lizenz: https://creativecommons.org/licenses/by-nc-sa/4.0
URL mynediad: https://archiv.ub.uni-marburg.de/diss/z2017/0337
https://doi.org/10.17192/z2017.0337

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