Towards Bioorthogonal Enzymatic Uncaging Reactions

Towards Bioorthogonal Enzymatic Uncaging Reactions

In this thesis, engineered cytochrome P450 monooxygenase mutants are reported as highly active and selective catalysts for the bioorthogonal uncaging of diferent ether protected substrates, including the successful transfer of the uncaging reaction into living bacteria. This proof-of-principle study...

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Библиографические подробности
Главный автор: Ritter, Cornelia
Другие авторы: Meggers, Eric (Prof. Dr.) (Научный руководитель)
Формат: Dissertation
Язык:английский
Опубликовано: Philipps-Universität Marburg 2016
Предметы:
caging
Enzym
Schutzgruppe
Chemische Biologie
P450
Aktivierung
Biowissenschaften, Biologie
Bioorthogonal
enzyme
chemical biology
activation
Life sciences
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Итог:In this thesis, engineered cytochrome P450 monooxygenase mutants are reported as highly active and selective catalysts for the bioorthogonal uncaging of diferent ether protected substrates, including the successful transfer of the uncaging reaction into living bacteria. This proof-of-principle study points towards the utility of bioorthogonal enzyme/protecting group pairs for applications in the life sciences.
DOI:10.17192/z2016.0051

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